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Target
G protein-activated inward rectifier potassium channel 1/4
Ligand
BDBM585694
Substrate
n/a
Meas. Tech.
IonWorks Quattro system
IC50
25.0±n/a nM
Citation
 Barbe, G; Bebernitz, GR; Geng, S; Gulgeze Efthymiou, HB; Liao, L; Ma, F; Mo, R; Parker, DT; Peng, Y; Peukert, S; Smith, N; Yamada, K; Yasoshima, K Naphthyridinone derivatives and their use in the treatment of arrhythmia US Patent  US11530213 Publication Date 12/20/2022 
Target
Name:
G protein-activated inward rectifier potassium channel 1/4
Synonyms:
GIRK1/4 channels | Kir3.1/Kir3.4
Type:
PROTEIN
Mol. Mass.:
n/a
Description:
n/a
Components:
This complex has 2 components.
Component 1
Name:
G protein-activated inward rectifier potassium channel 1
Synonyms:
GIRK-1 | GIRK1 | Inward rectifier K(+) channel Kir3.1 | KCNJ3 | KCNJ3_HUMAN | Potassium channel, inwardly rectifying subfamily J member 3
Type:
PROTEIN
Mol. Mass.:
56610.74
Organism:
Homo sapiens (Human)
Description:
ChEMBL_107915
Residue:
501
Sequence:
MSALRRKFGDDYQVVTTSSSGSGLQPQGPGQDPQQQLVPKKKRQRFVDKNGRCNVQHGNLGSETSRYLSDLFTTLVDLKWRWNLFIFILTYTVAWLFMASMWWVIAYTRGDLNKAHVGNYTPCVANVYNFPSAFLFFIETEATIGYGYRYITDKCPEGIILFLFQSILGSIVDAFLIGCMFIKMSQPKKRAETLMFSEHAVISMRDGKLTLMFRVGNLRNSHMVSAQIRCKLLKSRQTPEGEFLPLDQLELDVGFSTGADQLFLVSPLTICHVIDAKSPFYDLSQRSMQTEQFEIVVILEGIVETTGMTCQARTSYTEDEVLWGHRFFPVISLEEGFFKVDYSQFHATFEVPTPPYSVKEQEEMLLMSSPLIAPAITNSKERHNSVECLDGLDDITTKLPSKLQKITGREDFPKKLLRMSSTTSEKAYSLGDLPMKLQRISSVPGNSEEKLVSKTTKMLSDPMSQSVADLPPKLQKMAGGAARMEGNLPAKLRKMNSDRFT
  
Component 2
Name:
G protein-activated inward rectifier potassium channel 4
Synonyms:
CIR | Cardiac inward rectifier | GIRK-4 | GIRK4 | Heart KATP channel | IRK-4 | Inward rectifier K(+) channel Kir3.4 | KATP-1 | KCNJ5 | KCNJ5_HUMAN | Potassium channel, inwardly rectifying subfamily J member 5
Type:
PROTEIN
Mol. Mass.:
47658.06
Organism:
Homo sapiens (Human)
Description:
ChEMBL_107914
Residue:
419
Sequence:
MAGDSRNAMNQDMEIGVTPWDPKKIPKQARDYVPIATDRTRLLAEGKKPRQRYMEKSGKCNVHHGNVQETYRYLSDLFTTLVDLKWRFNLLVFTMVYTVTWLFFGFIWWLIAYIRGDLDHVGDQEWIPCVENLSGFVSAFLFSIETETTIGYGFRVITEKCPEGIILLLVQAILGSIVNAFMVGCMFVKISQPKKRAETLMFSNNAVISMRDEKLCLMFRVGDLRNSHIVEASIRAKLIKSRQTKEGEFIPLNQTDINVGFDTGDDRLFLVSPLIISHEINQKSPFWEMSQAQLHQEEFEVVVILEGMVEATGMTCQARSSYMDTEVLWGHRFTPVLTLEKGFYEVDYNTFHDTYETNTPSCCAKELAEMKREGRLLQYLPSPPLLGGCAEAGLDAEAEQNEEDEPKGLGGSREARGSV
  
Inhibitor
Name:
BDBM585694
Synonyms:
5-(2,5,8,11,14,17- hexaoxanonadecan-19-yloxy)-8- chloro-1-(2,6-dichlorophenyl)-2- methyl-1,6-naphthyridin-4(1H)-one | US11530213, Example 15
Type:
Small organic molecule
Emp. Form.:
C28H35Cl3N2O8
Mol. Mass.:
633.945
SMILES:
COCCOCCOCCOCCOCCOCCOc1ncc(Cl)c2n(c(C)cc(=O)c12)-c1c(Cl)cccc1Cl |(-8.28,2.64,;-8.68,1.16,;-7.59,.07,;-7.99,-1.42,;-6.9,-2.51,;-7.3,-4,;-6.21,-5.09,;-6.61,-6.57,;-5.84,-7.91,;-4.3,-7.91,;-3.53,-9.24,;-1.99,-9.24,;-1.99,-7.7,;-.66,-6.93,;-.66,-5.39,;.68,-4.62,;.68,-3.08,;2.01,-2.31,;2.01,-.77,;3.35,,;3.35,1.54,;2.01,2.31,;2.01,3.85,;3.35,4.62,;3.35,6.16,;4.68,3.85,;6.01,4.62,;7.35,3.85,;8.68,4.62,;7.35,2.31,;6.01,1.54,;6.01,,;4.68,2.31,;6.01,6.16,;4.68,6.93,;3.35,7.7,;4.68,8.47,;6.01,9.24,;7.35,8.47,;7.35,6.93,;8.68,6.16,)|
Structure:
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