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Target
G protein-activated inward rectifier potassium channel 1/4
Ligand
BDBM585712
Substrate
n/a
Meas. Tech.
IonWorks Quattro system
IC50
100.0±n/a nM
Citation
 Barbe, G; Bebernitz, GR; Geng, S; Gulgeze Efthymiou, HB; Liao, L; Ma, F; Mo, R; Parker, DT; Peng, Y; Peukert, S; Smith, N; Yamada, K; Yasoshima, K Naphthyridinone derivatives and their use in the treatment of arrhythmia US Patent  US11530213 Publication Date 12/20/2022 
Target
Name:
G protein-activated inward rectifier potassium channel 1/4
Synonyms:
GIRK1/4 channels | Kir3.1/Kir3.4
Type:
PROTEIN
Mol. Mass.:
n/a
Description:
n/a
Components:
This complex has 2 components.
Component 1
Name:
G protein-activated inward rectifier potassium channel 1
Synonyms:
GIRK-1 | GIRK1 | Inward rectifier K(+) channel Kir3.1 | KCNJ3 | KCNJ3_HUMAN | Potassium channel, inwardly rectifying subfamily J member 3
Type:
PROTEIN
Mol. Mass.:
56610.74
Organism:
Homo sapiens (Human)
Description:
ChEMBL_107915
Residue:
501
Sequence:
MSALRRKFGDDYQVVTTSSSGSGLQPQGPGQDPQQQLVPKKKRQRFVDKNGRCNVQHGNLGSETSRYLSDLFTTLVDLKWRWNLFIFILTYTVAWLFMASMWWVIAYTRGDLNKAHVGNYTPCVANVYNFPSAFLFFIETEATIGYGYRYITDKCPEGIILFLFQSILGSIVDAFLIGCMFIKMSQPKKRAETLMFSEHAVISMRDGKLTLMFRVGNLRNSHMVSAQIRCKLLKSRQTPEGEFLPLDQLELDVGFSTGADQLFLVSPLTICHVIDAKSPFYDLSQRSMQTEQFEIVVILEGIVETTGMTCQARTSYTEDEVLWGHRFFPVISLEEGFFKVDYSQFHATFEVPTPPYSVKEQEEMLLMSSPLIAPAITNSKERHNSVECLDGLDDITTKLPSKLQKITGREDFPKKLLRMSSTTSEKAYSLGDLPMKLQRISSVPGNSEEKLVSKTTKMLSDPMSQSVADLPPKLQKMAGGAARMEGNLPAKLRKMNSDRFT
  
Component 2
Name:
G protein-activated inward rectifier potassium channel 4
Synonyms:
CIR | Cardiac inward rectifier | GIRK-4 | GIRK4 | Heart KATP channel | IRK-4 | Inward rectifier K(+) channel Kir3.4 | KATP-1 | KCNJ5 | KCNJ5_HUMAN | Potassium channel, inwardly rectifying subfamily J member 5
Type:
PROTEIN
Mol. Mass.:
47658.06
Organism:
Homo sapiens (Human)
Description:
ChEMBL_107914
Residue:
419
Sequence:
MAGDSRNAMNQDMEIGVTPWDPKKIPKQARDYVPIATDRTRLLAEGKKPRQRYMEKSGKCNVHHGNVQETYRYLSDLFTTLVDLKWRFNLLVFTMVYTVTWLFFGFIWWLIAYIRGDLDHVGDQEWIPCVENLSGFVSAFLFSIETETTIGYGFRVITEKCPEGIILLLVQAILGSIVNAFMVGCMFVKISQPKKRAETLMFSNNAVISMRDEKLCLMFRVGDLRNSHIVEASIRAKLIKSRQTKEGEFIPLNQTDINVGFDTGDDRLFLVSPLIISHEINQKSPFWEMSQAQLHQEEFEVVVILEGMVEATGMTCQARSSYMDTEVLWGHRFTPVLTLEKGFYEVDYNTFHDTYETNTPSCCAKELAEMKREGRLLQYLPSPPLLGGCAEAGLDAEAEQNEEDEPKGLGGSREARGSV
  
Inhibitor
Name:
BDBM585712
Synonyms:
8-chloro-1-(2,6-dichlorophenyl)-5- ((3R,4S)-3,4-dihydroxypyrrolidin- 1-yl)-2-methyl-1,6-naphthyridin- 4(1H)-one | US11530213, Example 33
Type:
Small organic molecule
Emp. Form.:
C19H16Cl3N3O3
Mol. Mass.:
440.708
SMILES:
Cc1cc(=O)c2c(ncc(Cl)c2n1-c1c(Cl)cccc1Cl)N1C[C@H](O)[C@H](O)C1 |r,wD:25.28,23.26,(3.44,1.32,;2.1,.55,;2.1,-.99,;.77,-1.76,;.77,-3.3,;-.56,-.99,;-1.9,-1.76,;-3.23,-.99,;-3.23,.55,;-1.9,1.32,;-1.9,2.86,;-.56,.55,;.77,1.32,;.77,3.92,;-.56,4.69,;-1.9,3.92,;-.56,6.23,;.77,7,;2.1,6.23,;2.1,4.69,;3.44,3.92,;-1.9,-3.3,;-.65,-4.2,;-1.13,-5.67,;-.36,-7,;-2.67,-5.67,;-3.44,-7,;-3.14,-4.2,)|
Structure:
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