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Target
Protein cereblon
Ligand
BDBM585775
Substrate
n/a
Meas. Tech.
TBD
Ki
13600±n/a nM
Citation
 Gray, N; Zhang, T; Fischer, E; He, Z; Du, G; Donovan, K; Nowak, R; Yuan, JT Ligands to cereblon (CRBN) US Patent  US11530219 Publication Date 12/20/2022 
Target
Name:
Protein cereblon
Synonyms:
CRBN | CRBN_HUMAN
Type:
PROTEIN
Mol. Mass.:
50537.73
Organism:
Homo sapiens (Human)
Description:
ChEMBL_116917
Residue:
442
Sequence:
MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL
  
Inhibitor
Name:
BDBM585775
Synonyms:
US11530219, Compound 2
Type:
Small organic molecule
Emp. Form.:
C28H27N7O4
Mol. Mass.:
525.5585
SMILES:
O=C(CNc1ccnc(Nc2ccc3CCCc3c2)n1)Nc1cccc2C(=O)N(Cc12)C1CCC(=O)NC1=O
Structure:
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