Reaction Details Report a problem with these data
Target
Protein cereblon
Ligand
BDBM585781
Substrate
n/a
Meas. Tech.
TBD
Ki
6300±n/a nM
Citation
 Gray, N; Zhang, T; Fischer, E; He, Z; Du, G; Donovan, K; Nowak, R; Yuan, JT Ligands to cereblon (CRBN) US Patent  US11530219 Publication Date 12/20/2022 
Target
Name:
Protein cereblon
Synonyms:
CRBN | CRBN_HUMAN
Type:
PROTEIN
Mol. Mass.:
50537.73
Organism:
Homo sapiens (Human)
Description:
ChEMBL_116917
Residue:
442
Sequence:
MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL
  
Inhibitor
Name:
BDBM585781
Synonyms:
US11530219, Compound 9
Type:
Small organic molecule
Emp. Form.:
C26H24N6O5
Mol. Mass.:
500.506
SMILES:
COc1cccc(c1)-c1nccc(NCC(=O)Nc2cccc3C(=O)N(Cc23)C2CCC(=O)NC2=O)n1
Structure:
Search PDB for entries with ligand similarity: