Reaction Details Report a problem with these data
Target
Histone deacetylase 11
Ligand
BDBM50507688
Substrate
n/a
Meas. Tech.
Enzymatic Assay
IC50
13900±n/a nM
Citation
 Chern, J; Yu, C; Liu, J; Ho, Y; Wu, C; Huang, C; Hung, P Histone deacetylases (HDACs) inhibitors US Patent  US11535598 Publication Date 12/27/2022 
Target
Name:
Histone deacetylase 11
Synonyms:
HD11 | HDA11_HUMAN | HDAC11 | Human HDAC11
Type:
Chromatin regulator; hydrolase; repressor
Mol. Mass.:
39187.66
Organism:
Homo sapiens (Human)
Description:
Q96DB2
Residue:
347
Sequence:
MLHTTQLYQHVPETRWPIVYSPRYNITFMGLEKLHPFDAGKWGKVINFLKEEKLLSDSMLVEAREASEEDLLVVHTRRYLNELKWSFAVATITEIPPVIFLPNFLVQRKVLRPLRTQTGGTIMAGKLAVERGWAINVGGGFHHCSSDRGGGFCAYADITLAIKFLFERVEGISRATIIDLDAHQGNGHERDFMDDKRVYIMDVYNRHIYPGDRFAKQAIRRKVELEWGTEDDEYLDKVERNIKKSLQEHLPDVVVYNAGTDILEGDRLGGLSISPAGIVKRDELVFRMVRGRRVPILMVTSGGYQKRTARIIADSILNLFGLGLIGPESPSVSAQNSDTPLLPPAVP
  
Inhibitor
Name:
BDBM50507688
Synonyms:
CHEMBL4550214 | US11535598, Compound 5
Type:
Small organic molecule
Emp. Form.:
C24H21N3O4
Mol. Mass.:
415.4412
SMILES:
ONC(=O)c1ccc(Cn2c3ccccc3c(=O)n(CCc3ccccc3)c2=O)cc1
Structure:
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