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Target
Cathepsin D
Ligand
BDBM589175
Substrate
n/a
Meas. Tech.
In Vitro Enzymatic Cathepsin D (CatD) FRET Assay
IC50
14800±n/a nM
Citation
 Allen, JR; Bourbeau, MP; Chen, N; Liu, Q; Pettus, LH; Siegmund, AC Bicyclic thiazine and oxazine derivatives as beta-secretase inhibitors and methods of use US Patent  US11548903 Publication Date 1/10/2023 
Target
Name:
Cathepsin D
Synonyms:
CATD_HUMAN | CPSD | CTSD | Cathepsin D [Precursor] | Cathepsin D heavy chain | Cathepsin D light chain | Cathepsin D precursor
Type:
Enzyme
Mol. Mass.:
44551.72
Organism:
Homo sapiens (Human)
Description:
Human proCathepsin D (SwissProt accession number P07339) was expressed in Sf9 cells, purified, and autoactivated.
Residue:
412
Sequence:
MQPSSLLPLALCLLAAPASALVRIPLHKFTSIRRTMSEVGGSVEDLIAKGPVSKYSQAVPAVTEGPIPEVLKNYMDAQYYGEIGIGTPPQCFTVVFDTGSSNLWVPSIHCKLLDIACWIHHKYNSDKSSTYVKNGTSFDIHYGSGSLSGYLSQDTVSVPCQSASSASALGGVKVERQVFGEATKQPGITFIAAKFDGILGMAYPRISVNNVLPVFDNLMQQKLVDQNIFSFYLSRDPDAQPGGELMLGGTDSKYYKGSLSYLNVTRKAYWQVHLDQVEVASGLTLCKEGCEAIVDTGTSLMVGPVDEVRELQKAIGAVPLIQGEYMIPCEKVSTLPAITLKLGGKGYKLSPEDYTLKVSQAGKTLCLSGFMGMDIPPPSGPLWILGDVFIGRYYTVFDRDNNRVGFAEAARL
  
Inhibitor
Name:
BDBM589175
Synonyms:
US11548903, Example 108
Type:
Small organic molecule
Emp. Form.:
C22H17ClF3N7S
Mol. Mass.:
503.93
SMILES:
NC1=N[C@]2(CN(C[C@H]2CS1)c1ncc(F)cn1)c1cc(\C=C(/F)c2cnc(Cl)cn2)ccc1F |r,t:1|
Structure:
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