Reaction Details Report a problem with these data
Target
Interferon gamma receptor 1
Ligand
BDBM589748
Substrate
n/a
IC50
0.990±n/a nM
Citation
 Strohbach, JW; Akama, T; Blakemore, DC; Jacobs, RT; Jones, P; Limburg, DC; Oderinde, MS; Perry, MA; Plattner, JJ; Torella, RF; Zhou, Y; Yeoh, TY Substituted 1,2-oxaborolan-2-ols as PDE4 inhibitors US Patent  US11559538 Publication Date 1/24/2023 
Target
Name:
Interferon gamma receptor 1
Synonyms:
CDw119 | IFN-gamma receptor 1 | IFN-gamma-R-alpha | IFN-gamma-R1 | IFNGR1 | INGR1_HUMAN | Interferon gamma receptor alpha-chain
Type:
Enzyme Catalytic Domain
Mol. Mass.:
54381.75
Organism:
Homo sapiens (Human)
Description:
P15260
Residue:
489
Sequence:
MALLFLLPLVMQGVSRAEMGTADLGPSSVPTPTNVTIESYNMNPIVYWEYQIMPQVPVFTVEVKNYGVKNSEWIDACINISHHYCNISDHVGDPSNSLWVRVKARVGQKESAYAKSEEFAVCRDGKIGPPKLDIRKEEKQIMIDIFHPSVFVNGDEQEVDYDPETTCYIRVYNVYVRMNGSEIQYKILTQKEDDCDEIQCQLAIPVSSLNSQYCVSAEGVLHVWGVTTEKSKEVCITIFNSSIKGSLWIPVVAALLLFLVLSLVFICFYIKKINPLKEKSIILPKSLISVVRSATLETKPESKYVSLITSYQPFSLEKEVVCEEPLSPATVPGMHTEDNPGKVEHTEELSSITEVVTTEENIPDVVPGSHLTPIERESSSPLSSNQSEPGSIALNSYHSRNCSESDHSRNGFDTDSSCLESHSSLSDSEFPPNNKGEIKTEGQELITVIKAPTSFGYDKPHVLVDLLVDDSGKESLIGYRPTEDSKEFS
  
Inhibitor
Name:
BDBM589748
Synonyms:
US11559538, Example 12 | US11559538, Example 214 | US11559538, Example 44
Type:
Small organic molecule
Emp. Form.:
C17H19BFNO4
Mol. Mass.:
331.146
SMILES:
CCOc1cc(cc(F)c1OC)-c1cncc(c1)C1COB(O)C1
Structure:
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