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Target
Ubiquitin carboxyl-terminal hydrolase 14
Ligand
BDBM590244
Substrate
n/a
Meas. Tech.
Usp14 Inhibition Assay
IC50
<50±n/a nM
Citation
 Cullen, M; Bastos, CM; Parks, D; Munoz, B Proteasome activity enhancing compounds US Patent  US11560385 Publication Date 1/24/2023 
Target
Name:
Ubiquitin carboxyl-terminal hydrolase 14
Synonyms:
Deubiquitinating enzyme 14 | TGT | UBP14_HUMAN | USP14 | Ubiquitin thioesterase 14 | Ubiquitin-specific-processing protease 14
Type:
PROTEIN
Mol. Mass.:
56058.38
Organism:
Homo sapiens (Human)
Description:
ChEMBL_103728
Residue:
494
Sequence:
MPLYSVTVKWGKEKFEGVELNTDEPPMVFKAQLFALTGVQPARQKVMVKGGTLKDDDWGNIKIKNGMTLLMMGSADALPEEPSAKTVFVEDMTEEQLASAMELPCGLTNLGNTCYMNATVQCIRSVPELKDALKRYAGALRASGEMASAQYITAALRDLFDSMDKTSSSIPPIILLQFLHMAFPQFAEKGEQGQYLQQDANECWIQMMRVLQQKLEAIEDDSVKETDSSSASAATPSKKKSLIDQFFGVEFETTMKCTESEEEEVTKGKENQLQLSCFINQEVKYLFTGLKLRLQEEITKQSPTLQRNALYIKSSKISRLPAYLTIQMVRFFYKEKESVNAKVLKDVKFPLMLDMYELCTPELQEKMVSFRSKFKDLEDKKVNQQPNTSDKKSSPQKEVKYEPFSFADDIGSNNCGYYDLQAVLTHQGRSSSSGHYVSWVKRKQDEWIKFDDDKVSIVTPEDILRLSGGGDWHIAYVLLYGPRRVEIMEEESEQ
  
Inhibitor
Name:
BDBM590244
Synonyms:
US11560385, Compound 20B
Type:
Small organic molecule
Emp. Form.:
C25H26N4O2
Mol. Mass.:
414.4995
SMILES:
Cc1c(cc(\C=C\CCC#N)n1-c1ccc(cc1)C#N)C(=O)CN1C2CCC1[C@@H](O)C2 |r,TLB:22:23:28.30:26.25,THB:29:28:26.25:23|
Structure:
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