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Target
Ubiquitin carboxyl-terminal hydrolase 14
Ligand
BDBM590691
Substrate
n/a
Meas. Tech.
Usp14 Inhibition Assay
IC50
<50±n/a nM
Citation
 Cullen, M; Bastos, CM; Parks, D; Munoz, B Proteasome activity enhancing compounds US Patent  US11560385 Publication Date 1/24/2023 
Target
Name:
Ubiquitin carboxyl-terminal hydrolase 14
Synonyms:
Deubiquitinating enzyme 14 | TGT | UBP14_HUMAN | USP14 | Ubiquitin thioesterase 14 | Ubiquitin-specific-processing protease 14
Type:
PROTEIN
Mol. Mass.:
56058.38
Organism:
Homo sapiens (Human)
Description:
ChEMBL_103728
Residue:
494
Sequence:
MPLYSVTVKWGKEKFEGVELNTDEPPMVFKAQLFALTGVQPARQKVMVKGGTLKDDDWGNIKIKNGMTLLMMGSADALPEEPSAKTVFVEDMTEEQLASAMELPCGLTNLGNTCYMNATVQCIRSVPELKDALKRYAGALRASGEMASAQYITAALRDLFDSMDKTSSSIPPIILLQFLHMAFPQFAEKGEQGQYLQQDANECWIQMMRVLQQKLEAIEDDSVKETDSSSASAATPSKKKSLIDQFFGVEFETTMKCTESEEEEVTKGKENQLQLSCFINQEVKYLFTGLKLRLQEEITKQSPTLQRNALYIKSSKISRLPAYLTIQMVRFFYKEKESVNAKVLKDVKFPLMLDMYELCTPELQEKMVSFRSKFKDLEDKKVNQQPNTSDKKSSPQKEVKYEPFSFADDIGSNNCGYYDLQAVLTHQGRSSSSGHYVSWVKRKQDEWIKFDDDKVSIVTPEDILRLSGGGDWHIAYVLLYGPRRVEIMEEESEQ
  
Inhibitor
Name:
BDBM590691
Synonyms:
US11560385, Compound 132B
Type:
Small organic molecule
Emp. Form.:
C24H26FN3O2
Mol. Mass.:
407.4805
SMILES:
Cc1c(cc(C2CC(F)C2)n1-c1ccc(cc1)C#N)C(=O)CN1C2CCC1[C@@H](O)C2 |r,wD:27.31,TLB:21:22:27.29:25.24,THB:28:27:25.24:22,(-2.97,-.98,;-1.63,-.21,;-1.16,1.25,;.38,1.25,;.86,-.21,;2.35,-.61,;3.12,-1.95,;4.45,-1.18,;5.94,-1.58,;3.68,.16,;-.39,-1.12,;-.39,-2.66,;-1.72,-3.43,;-1.72,-4.97,;-.39,-5.74,;.95,-4.97,;.95,-3.43,;-.39,-7.28,;-.39,-8.82,;-2.24,2.34,;-3.73,1.94,;-1.85,3.83,;-2.93,4.92,;-4.03,6,;-2.7,6.77,;-2.3,8.26,;-3.63,7.49,;-5.17,7.49,;-5.94,8.82,;-5.57,6,)|
Structure:
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