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Target
Ubiquitin carboxyl-terminal hydrolase 14
Ligand
BDBM590692
Substrate
n/a
Meas. Tech.
Usp14 Inhibition Assay
IC50
<50±n/a nM
Citation
 Cullen, M; Bastos, CM; Parks, D; Munoz, B Proteasome activity enhancing compounds US Patent  US11560385 Publication Date 1/24/2023 
Target
Name:
Ubiquitin carboxyl-terminal hydrolase 14
Synonyms:
Deubiquitinating enzyme 14 | TGT | UBP14_HUMAN | USP14 | Ubiquitin thioesterase 14 | Ubiquitin-specific-processing protease 14
Type:
PROTEIN
Mol. Mass.:
56058.38
Organism:
Homo sapiens (Human)
Description:
ChEMBL_103728
Residue:
494
Sequence:
MPLYSVTVKWGKEKFEGVELNTDEPPMVFKAQLFALTGVQPARQKVMVKGGTLKDDDWGNIKIKNGMTLLMMGSADALPEEPSAKTVFVEDMTEEQLASAMELPCGLTNLGNTCYMNATVQCIRSVPELKDALKRYAGALRASGEMASAQYITAALRDLFDSMDKTSSSIPPIILLQFLHMAFPQFAEKGEQGQYLQQDANECWIQMMRVLQQKLEAIEDDSVKETDSSSASAATPSKKKSLIDQFFGVEFETTMKCTESEEEEVTKGKENQLQLSCFINQEVKYLFTGLKLRLQEEITKQSPTLQRNALYIKSSKISRLPAYLTIQMVRFFYKEKESVNAKVLKDVKFPLMLDMYELCTPELQEKMVSFRSKFKDLEDKKVNQQPNTSDKKSSPQKEVKYEPFSFADDIGSNNCGYYDLQAVLTHQGRSSSSGHYVSWVKRKQDEWIKFDDDKVSIVTPEDILRLSGGGDWHIAYVLLYGPRRVEIMEEESEQ
  
Inhibitor
Name:
BDBM590692
Synonyms:
US11560385, Compound 133B
Type:
Small organic molecule
Emp. Form.:
C25H29N3O2
Mol. Mass.:
403.5167
SMILES:
Cc1c(cc(CC2CCC2)n1-c1ccc(cc1)C#N)C(=O)CN1C2CCC1[C@@H](O)C2 |r,TLB:21:22:27.29:25.24,THB:28:27:25.24:22|
Structure:
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