Reaction Details Report a problem with these data
Target
DNA-directed RNA polymerase subunit beta'
Ligand
BDBM592164
Substrate
n/a
Meas. Tech.
Inhibition Assay
IC50
10000±n/a nM
Citation
 Ebright, RH; Ebright, YW; Freundlich, JS; Gallardo-Macias, R; Li, S Antibacterial agents: arylalkylcarboxamido phloroglucinols US Patent  US11572337 Publication Date 2/7/2023 
Target
Name:
DNA-directed RNA polymerase subunit beta'
Synonyms:
RNA polymerase subunit beta' | RNAP subunit beta' | RPOC_STAAU | Transcriptase subunit beta' | rpoC
Type:
Protein
Mol. Mass.:
118610.70
Organism:
n/a
Description:
P0C1T4
Residue:
1057
Sequence:
MIDVNNFHYMKIGLASPEKIRSWSFGEVKKPETINYRTLKPEKDGLFCERIFGPTKDWECSCGKYKRVRYKGMVCDRCGVEVTKSKVRRERMGHIELAAPVSHIWYFKGIPSRMGLLLDMSPRALEEVIYFASYVVVDPGPTGLEKKTLLSEAEFRDYYDKYPGQFVAKMGAEGIKDLLEEIDLDEELKLLRDELESATGQRLTRAIKRLEVVESFRNSGNKPSWMILDVLPIIPPEIRPMAQLDGGRFATSDLNDLYRRVINRNNRLKRLLDLGAPGIIVQNEKRMLQEAVDALIDNGRRGRPVTGPGNRPLKSLSHMLKGKQGRFRQNLLGKRVDYSGRSVIAVGPSLKMYQCGLPKEMALELFKPFVMKELVQREIATNIKNAKSKIERMDDEVWDVLEEVIREHPVLLNRAPTLHRLGIQAFEPTLVEGRAIRLHPLVTTAYNADFDGDQMAVHVPLSKEAQAEARMLMLAAQNILNPKDGKPVVTPSQDMVLGNYYLTLERKDAVNTGAIFNNTNEVLKAYANGFVHLHTRIGVHASSFNNPTFTEEQNKKILATSVGKIIFNEIIPDSFAYINEPTQENLERKTPNRNFIDPTTLGEGGLKEYFENEELIEPFNKKFLGNIIAEVFNRFSITDTSMMLDRMKDLGFKFSSKAGITVGVADIVVLPDKQQILDEHEKLVDRITKQFNRGLITEEERYNAVVEIWTDAKDQIQGELMQSLDKTNPIFMMSDSGARGNASNFTQLAGMRGLMAAPSGKIIELPITSSFREGLTVLEYFISTHGARKGLADTALKTADSGYLTRRLVDVAQDVIVREEDCGTDRGLLVSDIKEGTEMIEPFIERIEGRYSKETIRHPETDEIIIRPDELITPEIAKKITDAGIEQMYIRSAFTCNARHGVCEKCYGKNLATGEKVEVGEAVGTIAAQSIGEPGTQLTMRTFHTGGVAGSDITQGLPRIQEIFEARNPKGQAVITEIEGVVEDIKLAKDRQQEIVVKGANETRSYLASGTSRIIVEIGQPVQRGEVLTEGSIEPKNYLSVAGLNATESYLLKEVQK
 
Inhibitor
Name:
BDBM592164
Synonyms:
US11572337, Compound 0MTK256
Type:
Small organic molecule
Emp. Form.:
C21H18ClNO5
Mol. Mass.:
399.824
SMILES:
Oc1cc(O)c(C(=O)NCCc2ccc(Oc3cccc(Cl)c3)cc2)c(O)c1
Structure:
Search PDB for entries with ligand similarity: