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Target
DNA-directed RNA polymerase subunit beta'
Ligand
BDBM592165
Substrate
n/a
Meas. Tech.
Inhibition Assay
IC50
11000±n/a nM
Citation
 Ebright, RH; Ebright, YW; Freundlich, JS; Gallardo-Macias, R; Li, S Antibacterial agents: arylalkylcarboxamido phloroglucinols US Patent  US11572337 Publication Date 2/7/2023 
Target
Name:
DNA-directed RNA polymerase subunit beta'
Synonyms:
RNA polymerase subunit beta' | RNAP subunit beta' | RPOC_STAAU | Transcriptase subunit beta' | rpoC
Type:
Protein
Mol. Mass.:
118610.70
Organism:
n/a
Description:
P0C1T4
Residue:
1057
Sequence:
MIDVNNFHYMKIGLASPEKIRSWSFGEVKKPETINYRTLKPEKDGLFCERIFGPTKDWECSCGKYKRVRYKGMVCDRCGVEVTKSKVRRERMGHIELAAPVSHIWYFKGIPSRMGLLLDMSPRALEEVIYFASYVVVDPGPTGLEKKTLLSEAEFRDYYDKYPGQFVAKMGAEGIKDLLEEIDLDEELKLLRDELESATGQRLTRAIKRLEVVESFRNSGNKPSWMILDVLPIIPPEIRPMAQLDGGRFATSDLNDLYRRVINRNNRLKRLLDLGAPGIIVQNEKRMLQEAVDALIDNGRRGRPVTGPGNRPLKSLSHMLKGKQGRFRQNLLGKRVDYSGRSVIAVGPSLKMYQCGLPKEMALELFKPFVMKELVQREIATNIKNAKSKIERMDDEVWDVLEEVIREHPVLLNRAPTLHRLGIQAFEPTLVEGRAIRLHPLVTTAYNADFDGDQMAVHVPLSKEAQAEARMLMLAAQNILNPKDGKPVVTPSQDMVLGNYYLTLERKDAVNTGAIFNNTNEVLKAYANGFVHLHTRIGVHASSFNNPTFTEEQNKKILATSVGKIIFNEIIPDSFAYINEPTQENLERKTPNRNFIDPTTLGEGGLKEYFENEELIEPFNKKFLGNIIAEVFNRFSITDTSMMLDRMKDLGFKFSSKAGITVGVADIVVLPDKQQILDEHEKLVDRITKQFNRGLITEEERYNAVVEIWTDAKDQIQGELMQSLDKTNPIFMMSDSGARGNASNFTQLAGMRGLMAAPSGKIIELPITSSFREGLTVLEYFISTHGARKGLADTALKTADSGYLTRRLVDVAQDVIVREEDCGTDRGLLVSDIKEGTEMIEPFIERIEGRYSKETIRHPETDEIIIRPDELITPEIAKKITDAGIEQMYIRSAFTCNARHGVCEKCYGKNLATGEKVEVGEAVGTIAAQSIGEPGTQLTMRTFHTGGVAGSDITQGLPRIQEIFEARNPKGQAVITEIEGVVEDIKLAKDRQQEIVVKGANETRSYLASGTSRIIVEIGQPVQRGEVLTEGSIEPKNYLSVAGLNATESYLLKEVQK
 
Inhibitor
Name:
BDBM592165
Synonyms:
US11572337, Compound 0MTK257
Type:
Small organic molecule
Emp. Form.:
C22H21NO5
Mol. Mass.:
379.4058
SMILES:
Cc1ccc(Oc2ccc(CCNC(=O)c3c(O)cc(O)cc3O)cc2)cc1
Structure:
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