Reaction Details Report a problem with these data
Target
Vasopressin V1a receptor
Ligand
BDBM593606
Substrate
n/a
Meas. Tech.
Pharmacological Assay
Ki
0.316±n/a nM
Citation
 Runtz-Schmitt, V; Schnider, P; Dolente, C; Fasching, B Spiro-oxazolones US Patent  US11578077 Publication Date 2/14/2023 
Target
Name:
Vasopressin V1a receptor
Synonyms:
AVPR V1a | AVPR1 | AVPR1A | Antidiuretic hormone receptor 1a | V1AR_HUMAN | V1aR | VASOPRESSIN V1A | Vascular/hepatic-type arginine vasopressin receptor | Vasopressin V1 receptor | Vasopressin V1a receptor | Vasopressin receptor
Type:
Receptor
Mol. Mass.:
46820.18
Organism:
Homo sapiens (Human)
Description:
P37288
Residue:
418
Sequence:
MRLSAGPDAGPSGNSSPWWPLATGAGNTSREAEALGEGNGPPRDVRNEELAKLEIAVLAVTFAVAVLGNSSVLLALHRTPRKTSRMHLFIRHLSLADLAVAFFQVLPQMCWDITYRFRGPDWLCRVVKHLQVFGMFASAYMLVVMTADRYIAVCHPLKTLQQPARRSRLMIAAAWVLSFVLSTPQYFVFSMIEVNNVTKARDCWATFIQPWGSRAYVTWMTGGIFVAPVVILGTCYGFICYNIWCNVRGKTASRQSKGAEQAGVAFQKGFLLAPCVSSVKSISRAKIRTVKMTFVIVTAYIVCWAPFFIIQMWSVWDPMSVWTESENPTITITALLGSLNSCCNPWIYMFFSGHLLQDCVQSFPCCQNMKEKFNKEDTDSMSRRQTFYSNNRSPTNSTGMWKDSPKSSKSIKFIPVST
  
Inhibitor
Name:
BDBM593606
Synonyms:
2'-(1'H,3H-spiro[2-benzofuran-1,4'- piperidin]-1'-yl)-1,3-dihydro-4'H- spiro[indene-2,5'-[1,3]oxazol]-4'-one | US11578077, Example 1
Type:
Small organic molecule
Emp. Form.:
C23H22N2O3
Mol. Mass.:
374.4324
SMILES:
O=C1N=C(OC11Cc2ccccc2C1)N1CCC2(CC1)OCc1ccccc21 |c:2|
Structure:
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