Reaction Details Report a problem with these data
Target
D(3) dopamine receptor
Ligand
BDBM593840
Substrate
n/a
Meas. Tech.
Binding Inhibition for Dopamine D3 Receptor
Ki
0.034±n/a nM
Citation
 Tobinaga, H; Masuda, K Condensed ring compounds having dopamine D3 receptor antagonistic effect US Patent  US11578084 Publication Date 2/14/2023 
Target
Name:
D(3) dopamine receptor
Synonyms:
DRD3 | DRD3_HUMAN | Dopamine D3 receptor
Type:
PROTEIN
Mol. Mass.:
44213.40
Organism:
Homo sapiens
Description:
ChEMBL_105671
Residue:
400
Sequence:
MASLSQLSGHLNYTCGAENSTGASQARPHAYYALSYCALILAIVFGNGLVCMAVLKERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNFSRICCDVFVTLDVMMCTASILNLCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVWVLAFAVSCPLLFGFNTTGDPTVCSISNPDFVIYSSVVSFYLPFGVTVLVYARIYVVLKQRRRKRILTRQNSQCNSVRPGFPQQTLSPDPAHLELKRYYSICQDTALGGPGFQERGGELKREEKTRNSLSPTIAPKLSLEVRKLSNGRLSTSLKLGPLQPRGVPLREKKATQMVAIVLGAFIVCWLPFFLTHVLNTHCQTCHVSPELYSATTWLGYVNSALNPVIYTTFNIEFRKAFLKILSC
  
Inhibitor
Name:
BDBM593840
Synonyms:
US11578084, Compound I-123 | US11578084, Compound I-124
Type:
Small organic molecule
Emp. Form.:
C29H37F2N5O2
Mol. Mass.:
525.6332
SMILES:
CC(Oc1ccc2CCN(CC[C@H]3CC[C@@H](CC3)NC(=O)c3cccc4nn(C)cc34)CCc2n1)C(F)F |r,wU:12.11,wD:15.18,(-7.95,5.11,;-9.28,4.34,;-9.28,2.8,;-7.95,2.03,;-7.95,.49,;-6.62,-.28,;-5.28,.49,;-4.08,-.47,;-2.58,-.13,;-1.91,1.26,;-.37,1.26,;.4,-.07,;1.94,-.07,;2.71,1.26,;4.25,1.26,;5.02,-.07,;4.25,-1.41,;2.71,-1.41,;6.56,-.07,;7.33,-1.41,;6.56,-2.74,;8.87,-1.41,;9.64,-.07,;11.18,-.07,;11.95,-1.41,;11.18,-2.74,;11.66,-4.21,;10.41,-5.11,;10.41,-6.65,;9.17,-4.21,;9.64,-2.74,;-2.58,2.65,;-4.08,2.99,;-5.28,2.03,;-6.62,2.8,;-10.62,5.11,;-11.95,4.34,;-10.62,6.65,)|
Structure:
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