Reaction Details Report a problem with these data
Target
D(3) dopamine receptor
Ligand
BDBM593940
Substrate
n/a
Meas. Tech.
Binding Inhibition for Dopamine D3 Receptor
Ki
0.029±n/a nM
Citation
 Tobinaga, H; Masuda, K Condensed ring compounds having dopamine D3 receptor antagonistic effect US Patent  US11578084 Publication Date 2/14/2023 
Target
Name:
D(3) dopamine receptor
Synonyms:
DRD3 | DRD3_HUMAN | Dopamine D3 receptor
Type:
PROTEIN
Mol. Mass.:
44213.40
Organism:
Homo sapiens
Description:
ChEMBL_105671
Residue:
400
Sequence:
MASLSQLSGHLNYTCGAENSTGASQARPHAYYALSYCALILAIVFGNGLVCMAVLKERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNFSRICCDVFVTLDVMMCTASILNLCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVWVLAFAVSCPLLFGFNTTGDPTVCSISNPDFVIYSSVVSFYLPFGVTVLVYARIYVVLKQRRRKRILTRQNSQCNSVRPGFPQQTLSPDPAHLELKRYYSICQDTALGGPGFQERGGELKREEKTRNSLSPTIAPKLSLEVRKLSNGRLSTSLKLGPLQPRGVPLREKKATQMVAIVLGAFIVCWLPFFLTHVLNTHCQTCHVSPELYSATTWLGYVNSALNPVIYTTFNIEFRKAFLKILSC
  
Inhibitor
Name:
BDBM593940
Synonyms:
US11578084, Compound III-3
Type:
Small organic molecule
Emp. Form.:
C26H34F4N4O2
Mol. Mass.:
510.5674
SMILES:
Cc1cc(CC(=O)N[C@H]2CC[C@](F)(CCN3CCc4ccc(CCC(F)(F)F)nc4CC3)CC2)on1 |r,wU:11.12,wD:8.7,11.11,(13.49,2.1,;11.95,2.1,;10.92,3.24,;9.52,2.61,;8.18,3.38,;6.85,2.61,;6.85,1.07,;5.52,3.38,;4.18,2.61,;2.85,3.38,;1.51,2.61,;1.51,1.07,;1.51,-.47,;.18,.3,;-1.15,1.07,;-2.49,.3,;-2.37,-1.23,;-3.5,-2.28,;-5.02,-2.05,;-5.79,-3.38,;-7.33,-3.38,;-8.1,-2.05,;-9.64,-2.05,;-10.41,-.72,;-11.95,-.72,;-12.72,.62,;-13.49,-.72,;-12.72,-2.05,;-7.33,-.72,;-5.79,-.72,;-5.23,.72,;-3.76,1.17,;2.85,.3,;4.18,1.07,;9.68,1.08,;11.18,.76,)|
Structure:
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