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Target
Mannan-binding lectin serine protease 2
Ligand
BDBM595148
Substrate
n/a
Meas. Tech.
Enzymatic Assay for MASP-2
Ki
<500±n/a nM
Citation
 Cutshall, NS; Gage, JL; Gruswitz, FA; Khalaf, J; Little, TL; Metz, M; Nguyen, JH; Nollert von Specht, PK; Tsoung, J; Cicirelli, M; Goldstein, SR; Keshipeddy, SK; Kwon, DY; Lemus, RH; Vaddela, SB MASP-2 inhibitors and methods of use US Patent  US11584714 Publication Date 2/21/2023 
Target
Name:
Mannan-binding lectin serine protease 2
Synonyms:
MASP-2 | MASP2_MOUSE | MBL-associated serine protease 2 | Mannose-binding protein-associated serine protease 2 | Masp2
Type:
Protein
Mol. Mass.:
75509.67
Organism:
Mouse
Description:
Q91WP0
Residue:
685
Sequence:
MRLLIFLGLLWSLVATLLGSKWPEPVFGRLVSPGFPEKYADHQDRSWTLTAPPGYRLRLYFTHFDLELSYRCEYDFVKLSSGTKVLATLCGQESTDTEQAPGNDTFYSLGPSLKVTFHSDYSNEKPFTGFEAFYAAEDVDECRVSLGDSVPCDHYCHNYLGGYYCSCRAGYVLHQNKHTCSALCSGQVFTGRSGYLSSPEYPQPYPKLSSCTYSIRLEDGFSVILDFVESFDVETHPEAQCPYDSLKIQTDKGEHGPFCGKTLPPRIETDSHKVTITFATDESGNHTGWKIHYTSTARPCPDPTAPPNGSISPVQAIYVLKDRFSVFCKTGFELLQGSVPLKSFTAVCQKDGSWDRPMPECSIIDCGPPDDLPNGHVDYITGPEVTTYKAVIQYSCEETFYTMSSNGKYVCEADGFWTSSKGEKLPPVCEPVCGLSTHTIGGRIVGGQPAKPGDFPWQVLLLGQTTAAAGALIHDNWVLTAAHAVYEKRMAASSLNIRMGILKRLSPHYTQAWPEEIFIHEGYTHGAGFDNDIALIKLKNKVTINGSIMPVCLPRKEAASLMRTDFTGTVAGWGLTQKGLLARNLMFVDIPIADHQKCTAVYEKLYPGVRVSANMLCAGLETGGKDSCRGDSGGALVFLDNETQRWFVGGIVSWGSINCGAADQYGVYTKVINYIPWIENIISNF
  
Inhibitor
Name:
BDBM595148
Synonyms:
US11584714, Compound 1236
Type:
Small organic molecule
Emp. Form.:
C30H37N5O4
Mol. Mass.:
531.6459
SMILES:
C[C@H](NC(=O)[C@@H](CCc1ccccc1)NCc1ccc(OCCO)cc1)C(=O)NCc1ccc(cc1)C(N)=N |r|
Structure:
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