Target
Mannan-binding lectin serine protease 2
Ligand
BDBM595259
Substrate
n/a
Meas. Tech.
Enzymatic Assay for MASP-2
Ki
<500±n/a nM
Citation
 Cutshall, NSGage, JLGruswitz, FAKhalaf, JLittle, TLMetz, MNguyen, JHNollert von Specht, PKTsoung, JCicirelli, MGoldstein, SRKeshipeddy, SKKwon, DYLemus, RHVaddela, SB MASP-2 inhibitors and methods of use US Patent  US11584714 Publication Date 2/21/2023 
Target
Name:
Mannan-binding lectin serine protease 2
Synonyms:
MASP-2 | MASP2_MOUSE | MBL-associated serine protease 2 | Mannose-binding protein-associated serine protease 2 | Masp2
Type:
Protein
Mol. Mass.:
75509.67
Organism:
Mouse
Description:
Q91WP0
Residue:
685
Sequence:
MRLLIFLGLLWSLVATLLGSKWPEPVFGRLVSPGFPEKYADHQDRSWTLTAPPGYRLRLYFTHFDLELSYRCEYDFVKLSSGTKVLATLCGQESTDTEQAPGNDTFYSLGPSLKVTFHSDYSNEKPFTGFEAFYAAEDVDECRVSLGDSVPCDHYCHNYLGGYYCSCRAGYVLHQNKHTCSALCSGQVFTGRSGYLSSPEYPQPYPKLSSCTYSIRLEDGFSVILDFVESFDVETHPEAQCPYDSLKIQTDKGEHGPFCGKTLPPRIETDSHKVTITFATDESGNHTGWKIHYTSTARPCPDPTAPPNGSISPVQAIYVLKDRFSVFCKTGFELLQGSVPLKSFTAVCQKDGSWDRPMPECSIIDCGPPDDLPNGHVDYITGPEVTTYKAVIQYSCEETFYTMSSNGKYVCEADGFWTSSKGEKLPPVCEPVCGLSTHTIGGRIVGGQPAKPGDFPWQVLLLGQTTAAAGALIHDNWVLTAAHAVYEKRMAASSLNIRMGILKRLSPHYTQAWPEEIFIHEGYTHGAGFDNDIALIKLKNKVTINGSIMPVCLPRKEAASLMRTDFTGTVAGWGLTQKGLLARNLMFVDIPIADHQKCTAVYEKLYPGVRVSANMLCAGLETGGKDSCRGDSGGALVFLDNETQRWFVGGIVSWGSINCGAADQYGVYTKVINYIPWIENIISNF
  
Inhibitor
Name:
BDBM595259
Synonyms:
US11584714, Compound 1347
Type:
Small organic molecule
Emp. Form.:
C22H30N6O2
Mol. Mass.:
410.5126
SMILES:
C[C@H](NC(=O)[C@H]1CN(Cc2ccccc2)CCN1)C(=O)NCc1ccc(N)nc1C |r|
Structure:
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