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Target
Diacylglycerol kinase alpha [9-727]
Ligand
BDBM594552
Substrate
n/a
Meas. Tech.
In Vitro DGK Inhibition Assay
IC50
17.0±n/a nM
Citation
 Velaparthi, U; Olson, RE; Darne, CP; Dasgupta, B; Warrier, JS; Rahaman, H; Jalagam, PR; Roy, S; Grunenfelder, DC Substituted pyridopyrimidinonyl compounds useful as T cell activators US Patent  US11584747 Publication Date 2/21/2023 
Target
Name:
Diacylglycerol kinase alpha [9-727]
Synonyms:
DAGK | DAGK1 | DGKA | DGKA_HUMAN
Type:
PROTEIN
Mol. Mass.:
80817.73
Organism:
Homo sapiens
Description:
P23743 [9-727]
Residue:
719
Sequence:
SPSDFAQLQKYMEYSTKKVSDVLKLFEDGEMAKYVQGDAIGYEGFQQFLKIYLEVDNVPRHLSLALFQSFETGHCLNETNVTKDVVCLNDVSCYFSLLEGGRPEDKLEFTFKLYDTDRNGILDSSEVDKIILQMMRVAEYLDWDVSELRPILQEMMKEIDYDGSGSVSQAEWVRAGATTVPLLVLLGLEMTLKDDGQHMWRPKRFPRPVYCNLCESSIGLGKQGLSCNLCKYTVHDQCAMKALPCEVSTYAKSRKDIGVQSHVWVRGGCESGRCDRCQKKIRIYHSLTGLHCVWCHLEIHDDCLQAVGHECDCGLLRDHILPPSSIYPSVLASGPDRKNSKTSQKTMDDLNLSTSEALRIDPVPNTHPLLVFVNPKSGGKQGQRVLWKFQYILNPRQVFNLLKDGPEIGLRLFKDVPDSRILVCGGDGTVGWILETIDKANLPVLPPVAVLPLGTGNDLARCLRWGGGYEGQNLAKILKDLEMSKVVHMDRWSVEVIPQQTEEKSDPVPFQIINNYFSIGVDASIAHRFHIMREKYPEKFNSRMKNKLWYFEFATSESIFSTCKKLEESLTVEICGKPLDLSNLSLEGIAVLNIPSMHGGSNLWGDTRRPHGDIYGINQALGATAKVITDPDILKTCVPDLSDKRLEVVGLEGAIEMGQIYTKLKNAGRRLAKCSEITFHTTKTLPMQIDGEPWMQTPCTIKITHKNQMPMLMGPPPRS
  
Inhibitor
Name:
BDBM594552
Synonyms:
US11584747, Example 363 | US11584747, Example 364
Type:
Small organic molecule
Emp. Form.:
C25H32N8O2
Mol. Mass.:
476.574
SMILES:
CCC(N1C[C@H](CC)N(C[C@H]1CC)c1nc(=O)n(C)c2ccc(nc12)C#N)c1nc(no1)C1CC1 |r|
Structure:
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