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Target
Protein cereblon
Ligand
BDBM594657
Substrate
n/a
Meas. Tech.
Fluorescence Direct Binding Asaay
Kd
2.00±n/a nM
Citation
 Nasveschuk, CG; Dey, F; Goergler, A; Kuhn, B; Norcross, R; Roever, S; Schmid, P Spirocyclic compounds US Patent  US11584748 Publication Date 2/21/2023 
Target
Name:
Protein cereblon
Synonyms:
CRBN | CRBN_HUMAN
Type:
PROTEIN
Mol. Mass.:
50537.73
Organism:
Homo sapiens (Human)
Description:
ChEMBL_116917
Residue:
442
Sequence:
MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL
  
Inhibitor
Name:
BDBM594657
Synonyms:
US11584748, Example 24 | tert-Butyl 6-(6,8-dioxo-2,7-diazaspiro[4.5]decan-2-yl)nicotinate
Type:
Small organic molecule
Emp. Form.:
C18H23N3O4
Mol. Mass.:
345.3929
SMILES:
CC(C)(C)OC(=O)c1ccc(nc1)N1CCC2(C1)CCC(=O)NC2=O
Structure:
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