Reaction Details Report a problem with these data
Target
Beclin 1/Bcl-2
Ligand
BDBM595513
Substrate
n/a
Meas. Tech.
High-Throughput Assay
IC50
982±n/a nM
Citation
 Brabander, JD; Liang, Q; Levine, B; Chiang, W Small molecule inducers of autophagy US Patent  US11591319 Publication Date 2/28/2023 
Target
Name:
Beclin 1/Bcl-2
Synonyms:
n/a
Type:
Protein
Mol. Mass.:
n/a
Description:
n/a
Components:
This complex has 2 components.
Component 1
Name:
Beclin-1
Synonyms:
BECN1 | BECN1_HUMAN | Beclin-1-C 35 kDa | Beclin-1-C 37 kDa | Coiled-coil myosin-like BCL2-interacting protein | GT197 | Protein GT197
Type:
PROTEIN
Mol. Mass.:
51874.54
Organism:
Homo sapiens
Description:
ChEMBL_118255
Residue:
450
Sequence:
MEGSKTSNNSTMQVSFVCQRCSQPLKLDTSFKILDRVTIQELTAPLLTTAQAKPGETQEEETNSGEEPFIETPRQDGVSRRFIPPARMMSTESANSFTLIGEASDGGTMENLSRRLKVTGDLFDIMSGQTDVDHPLCEECTDTLLDQLDTQLNVTENECQNYKRCLEILEQMNEDDSEQLQMELKELALEEERLIQELEDVEKNRKIVAENLEKVQAEAERLDQEEAQYQREYSEFKRQQLELDDELKSVENQMRYAQTQLDKLKKTNVFNATFHIWHSGQFGTINNFRLGRLPSVPVEWNEINAAWGQTVLLLHALANKMGLKFQRYRLVPYGNHSYLESLTDKSKELPLYCSGGLRFFWDNKFDHAMVAFLDCVQQFKEEVEKGETRFCLPYRMDVEKGKIEDTGGSGGSYSIKTQFNSEEQWTKALKFMLTNLKWGLAWVSSQFYNK
  
Component 2
Name:
Apoptosis regulator Bcl-2
Synonyms:
Apoptosis regulator Bcl-2 Protein | B-cell lymphoma 2 protein (Bcl-2) | BCL-2 | BCL2 | BCL2_HUMAN | Bcl-2 Protein
Type:
Homodimer or heterodimer
Mol. Mass.:
26269.11
Organism:
Homo sapiens (Human)
Description:
P10415
Residue:
239
Sequence:
MAHAGRTGYDNREIVMKYIHYKLSQRGYEWDAGDVGAAPPGAAPAPGIFSSQPGHTPHPAASRDPVARTSPLQTPAAPGAAAGPALSPVPPVVHLTLRQAGDDFSRRYRRDFAEMSSQLHLTPFTARGRFATVVEELFRDGVNWGRIVAFFEFGGVMCVESVNREMSPLVDNIALWMTEYLNRHLHTWIQDNGGWDAFVELYGPSMRPLFDFSWLSLKTLLSLALVGACITLGAYLGHK
  
Inhibitor
Name:
BDBM595513
Synonyms:
US11591319, ID lqr-8-231
Type:
Small organic molecule
Emp. Form.:
C25H24BrN3O4
Mol. Mass.:
510.38
SMILES:
CC(C)(C)OC(=O)Nc1ccc(cc1)C1=NN(C(C1)c1ccco1)C(=O)c1ccc(Br)cc1 |t:15|
Structure:
Search PDB for entries with ligand similarity: