Reaction Details Report a problem with these data
Target
Serine/threonine-protein kinase pim-1
Ligand
BDBM597565
Substrate
n/a
Meas. Tech.
Kinase Biological Assay
Kd
>100±n/a nM
Citation
 Blaquiere, NA; Huang, RY; Kirrane, Jr., TM; Kordikowski, A; Mata, A; Sarko, CR; Taft, BR; Waldron, GL; Yokokawa, F; Zhu, T Compounds and compositions for the treatment of parasitic diseases US Patent  US11597733 Publication Date 3/7/2023 
Target
Name:
Serine/threonine-protein kinase pim-1
Synonyms:
PIM-1 Kinase | PIM1 | PIM1_HUMAN | Proto-oncogene serine/threonine-protein kinase Pim-1 | Serine/threonine-protein kinase (PIM1) | Serine/threonine-protein kinase PIM | Serine/threonine-protein kinase PIM1 | Serine/threonine-protein kinase pim-1 (PIM1)
Type:
Protein
Mol. Mass.:
35681.82
Organism:
Homo sapiens (Human)
Description:
P11309
Residue:
313
Sequence:
MLLSKINSLAHLRAAPCNDLHATKLAPGKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFRQRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDVLLPQETAEIHLHSLSPGPSK
  
Inhibitor
Name:
BDBM597565
Synonyms:
US11597733, Example 30-0 | US11597733, Example 30-16
Type:
Small organic molecule
Emp. Form.:
C21H28N6O2S
Mol. Mass.:
428.551
SMILES:
CCOc1nc(ccc1-c1cnc2sc(nn12)N1C[C@H]2OCC[C@H](N)[C@H]2C1)C(C)C |r|
Structure:
Search PDB for entries with ligand similarity: