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Target
D(3) dopamine receptor
Ligand
BDBM50527993
Substrate
n/a
Meas. Tech.
D3 Radioligand Binding Assay
EC50
4.30±n/a nM
Citation
 Sibley, DR; Moritz, AE; Free, RB; Steiner, JP; Southall, NT; Ferrer, M; Hu, X; Weiner, WS; Aubé, J; Frankowski, K Selective D3 dopamine receptor agonists and methods of their use US Patent  US11634404 Publication Date 4/25/2023 
Target
Name:
D(3) dopamine receptor
Synonyms:
DRD3 | DRD3_HUMAN | Dopamine D3 receptor
Type:
PROTEIN
Mol. Mass.:
44213.40
Organism:
Homo sapiens
Description:
ChEMBL_105671
Residue:
400
Sequence:
MASLSQLSGHLNYTCGAENSTGASQARPHAYYALSYCALILAIVFGNGLVCMAVLKERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNFSRICCDVFVTLDVMMCTASILNLCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVWVLAFAVSCPLLFGFNTTGDPTVCSISNPDFVIYSSVVSFYLPFGVTVLVYARIYVVLKQRRRKRILTRQNSQCNSVRPGFPQQTLSPDPAHLELKRYYSICQDTALGGPGFQERGGELKREEKTRNSLSPTIAPKLSLEVRKLSNGRLSTSLKLGPLQPRGVPLREKKATQMVAIVLGAFIVCWLPFFLTHVLNTHCQTCHVSPELYSATTWLGYVNSALNPVIYTTFNIEFRKAFLKILSC
  
Inhibitor
Name:
BDBM50527993
Synonyms:
CHEMBL4458958 | US11634404, Compound 74
Type:
Small organic molecule
Emp. Form.:
C21H24N4O3
Mol. Mass.:
380.4403
SMILES:
COc1ccc2cc([nH]c2c1)C(=O)N1CCN(CCOc2cccnc2)CC1
Structure:
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