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Target
Serine/threonine-protein kinase Chk2
Ligand
BDBM601395
Substrate
n/a
Meas. Tech.
Activity Test of Compounds in the CHK1 Coupled Reaction System
IC50
13.0±n/a nM
Citation
 Liao, Y; Qian, W; Wei, C; Xiao, Y; Xi, Z; Zhang, C; Li, J; Chen, S Diazaindole derivative and use thereof as CHK1 inhibitor US Patent  US11634424 Publication Date 4/25/2023 
Target
Name:
Serine/threonine-protein kinase Chk2
Synonyms:
CDS1 | CHEK2 | CHK2 | CHK2_HUMAN | Checkpoint Kinase (Chk2) | RAD53 | Serine/threonine-protein kinase Chek2 | Serine/threonine-protein kinase Chk1/2
Type:
Protein
Mol. Mass.:
60908.59
Organism:
Homo sapiens (Human)
Description:
O96017
Residue:
543
Sequence:
MSRESDVEAQQSHGSSACSQPHGSVTQSQGSSSQSQGISSSSTSTMPNSSQSSHSSSGTLSSLETVSTQELYSIPEDQEPEDQEPEEPTPAPWARLWALQDGFANLECVNDNYWFGRDKSCEYCFDEPLLKRTDKYRTYSKKHFRIFREVGPKNSYIAYIEDHSGNGTFVNTELVGKGKRRPLNNNSEIALSLSRNKVFVFFDLTVDDQSVYPKALRDEYIMSKTLGSGACGEVKLAFERKTCKKVAIKIISKRKFAIGSAREADPALNVETEIEILKKLNHPCIIKIKNFFDAEDYYIVLELMEGGELFDKVVGNKRLKEATCKLYFYQMLLAVQYLHENGIIHRDLKPENVLLSSQEEDCLIKITDFGHSKILGETSLMRTLCGTPTYLAPEVLVSVGTAGYNRAVDCWSLGVILFICLSGYPPFSEHRTQVSLKDQITSGKYNFIPEVWAEVSEKALDLVKKLLVVDPKARFTTEEALRHPWLQDEDMKRKFQDLLSEENESTALPQVLAQPSTSRKRPREGEAEGAETTKRPAVCAAVL
  
Inhibitor
Name:
BDBM601395
Synonyms:
US11634424, Compound 7
Type:
Small organic molecule
Emp. Form.:
C21H22FN7O
Mol. Mass.:
407.4441
SMILES:
COc1cccc(F)c1-c1cc(Nc2cnc3ccn(C4CCNCC4)c3n2)n[nH]1
Structure:
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