Reaction Details Report a problem with these data
Target
Nucleoprotein
Ligand
BDBM601467
Substrate
n/a
Meas. Tech.
Plaque Reduction Assay
EC50
73.0±n/a nM
Citation
 Cockerill, GS; Good, J; Cochrane, EJ Pharmaceutical compounds US Patent  US11634425 Publication Date 4/25/2023 
Target
Name:
Nucleoprotein
Synonyms:
N | NCAP_HRSVA | Nucleocapsid protein | Protein N
Type:
PROTEIN
Mol. Mass.:
43455.45
Organism:
Human respiratory syncytial virus A (strain A2)
Description:
ChEMBL_117398
Residue:
391
Sequence:
MALSKVKLNDTLNKDQLLSSSKYTIQRSTGDSIDTPNYDVQKHINKLCGMLLITEDANHKFTGLIGMLYAMSRLGREDTIKILRDAGYHVKANGVDVTTHRQDINGKEMKFEVLTLASLTTEIQINIEIESRKSYKKMLKEMGEVAPEYRHDSPDCGMIILCIAALVITKLAAGDRSGLTAVIRRANNVLKNEMKRYKGLLPKDIANSFYEVFEKHPHFIDVFVHFGIAQSSTRGGSRVEGIFAGLFMNAYGAGQVMLRWGVLAKSVKNIMLGHASVQAEMEQVVEVYEYAQKLGGEAGFYHILNNPKASLLSLTQFPHFSSVVLGNAAGLGIMGEYRGTPRNQDLYDAAKAYAEQLKENGVINYSVLDLTAEELEAIKHQLNPKDNDVEL
  
Inhibitor
Name:
BDBM601467
Synonyms:
2-(2-Fluoro-3- methoxyphenyl)-N- [(3S)-9-fluoro-2-oxo-5- phenyl-1,3-dihydro-1,4- benzodiazepin-3- yl]pyrazolo[1,5- a]pyrimidine-3- carboxamide | US11634425, Example 9
Type:
Small organic molecule
Emp. Form.:
C29H20F2N6O3
Mol. Mass.:
538.5043
SMILES:
COc1cccc(-c2nn3cccnc3c2C(=O)N[C@H]2N=C(c3ccccc3)c3cccc(F)c3NC2=O)c1F |t:22|
Structure:
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