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Target
Bromodomain-containing protein 2
Ligand
BDBM543516
Substrate
n/a
Meas. Tech.
Alpha Screen Assay
IC50
4.58±n/a nM
Citation
 Schönbrunn, E; Lawrence, NJ; Lawrence, HR BRD4-kinase inhibitors as cancer therapeutics US Patent  US11643396 Publication Date 5/9/2023 
Target
Name:
Bromodomain-containing protein 2
Synonyms:
BRD2 | BRD2_HUMAN | Bromodomain and extra-terminal motif (BET) | Bromodomain-containing protein 2 | Bromodomain-containing protein 2 (BRD2) | KIAA9001 | RING3
Type:
Protein
Mol. Mass.:
88085.95
Organism:
Homo sapiens (Human)
Description:
P25440
Residue:
801
Sequence:
MLQNVTPHNKLPGEGNAGLLGLGPEAAAPGKRIRKPSLLYEGFESPTMASVPALQLTPANPPPPEVSNPKKPGRVTNQLQYLHKVVMKALWKHQFAWPFRQPVDAVKLGLPDYHKIIKQPMDMGTIKRRLENNYYWAASECMQDFNTMFTNCYIYNKPTDDIVLMAQTLEKIFLQKVASMPQEEQELVVTIPKNSHKKGAKLAALQGSVTSAHQVPAVSSVSHTALYTPPPEIPTTVLNIPHPSVISSPLLKSLHSAGPPLLAVTAAPPAQPLAKKKGVKRKADTTTPTPTAILAPGSPASPPGSLEPKAARLPPMRRESGRPIKPPRKDLPDSQQQHQSSKKGKLSEQLKHCNGILKELLSKKHAAYAWPFYKPVDASALGLHDYHDIIKHPMDLSTVKRKMENRDYRDAQEFAADVRLMFSNCYKYNPPDHDVVAMARKLQDVFEFRYAKMPDEPLEPGPLPVSTAMPPGLAKSSSESSSEESSSESSSEEEEEEDEEDEEEEESESSDSEEERAHRLAELQEQLRAVHEQLAALSQGPISKPKRKREKKEKKKKRKAEKHRGRAGADEDDKGPRAPRPPQPKKSKKASGSGGGSAALGPSGFGPSGGSGTKLPKKATKTAPPALPTGYDSEEEEESRPMSYDEKRQLSLDINKLPGEKLGRVVHIIQAREPSLRDSNPEEIEIDFETLKPSTLRELERYVLSCLRKKPRKPYTIKKPVGKTKEELALEKKRELEKRLQDVSGQLNSTKKPPKKANEKTESSSAQQVAVSRLSASSSSSDSSSSSSSSSSSDTSDSDSG
  
Inhibitor
Name:
BDBM543516
Synonyms:
US11279703, TABLE 6.119 | US11279703, TABLE 6.128 | US11279703, TABLE 6.149 | US11279703, TABLE 6.154 | US11279703, TABLE 6.168 | US11279703, TABLE 6.181 | US11279703, TABLE 6.194 | US11279703, TABLE 6.199 | US11279703, TABLE 6.204 | US11279703, TABLE 6.215 | US11279703, TABLE 6.244 | US11279703, TABLE 6.262 | US11279703, TABLE 6.276 | US11279703, TABLE 6.298 | US11279703, TABLE 6.307 | US11279703, TABLE 6.314 | US11279703, TABLE 6.319 | US11279703, TABLE 6.328 | US11279703, TABLE 6.37 | US11643396, Example MA2-014
Type:
Small organic molecule
Emp. Form.:
C26H35N7O2S
Mol. Mass.:
509.667
SMILES:
CN1CCN(CC1)c1ccc(Nc2ncc(C)c(Nc3cccc(NS(=O)(=O)C(C)(C)C)c3)n2)cc1
Structure:
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