Reaction Details Report a problem with these data
Target
Serine/threonine-protein kinase pim-1
Ligand
BDBM602107
Substrate
n/a
Meas. Tech.
Pim-1 Inhibitory Activity Assay
Ki
0.006±n/a nM
Citation
 Inoue, M; Ogoshi, Y; Furukawa, T; Machida, T; Mitani, I; Harada, K; Nakagawa, Y; Yamaoka, N Tetrahydrobenzofurodiazepinone compound and pharmaceutical use thereof US Patent  US11643417 Publication Date 5/9/2023 
Target
Name:
Serine/threonine-protein kinase pim-1
Synonyms:
PIM-1 Kinase | PIM1 | PIM1_HUMAN | Proto-oncogene serine/threonine-protein kinase Pim-1 | Serine/threonine-protein kinase (PIM1) | Serine/threonine-protein kinase PIM | Serine/threonine-protein kinase PIM1 | Serine/threonine-protein kinase pim-1 (PIM1)
Type:
Protein
Mol. Mass.:
35681.82
Organism:
Homo sapiens (Human)
Description:
P11309
Residue:
313
Sequence:
MLLSKINSLAHLRAAPCNDLHATKLAPGKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFRQRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDVLLPQETAEIHLHSLSPGPSK
  
Inhibitor
Name:
BDBM602107
Synonyms:
US11643417, Ex. No. 120
Type:
Small organic molecule
Emp. Form.:
C21H23F5N2O4
Mol. Mass.:
462.4103
SMILES:
OCC1(O)CCC(CC1)C(F)(F)CN1CCNC(=O)c2oc3ccc(cc3c12)C(F)(F)F |(7.13,.13,;5.59,.13,;4.82,1.46,;6.31,1.86,;3.67,.45,;2.21,.95,;1.91,2.46,;3.07,3.47,;4.53,2.98,;.45,2.96,;-.56,4.12,;.95,4.42,;-.71,1.94,;-2.16,2.44,;-2.35,3.97,;-3.66,4.78,;-5.11,4.26,;-5.61,2.8,;-7.13,2.62,;-4.78,1.51,;-5.4,.1,;-4.26,-.93,;-4.26,-2.47,;-2.92,-3.24,;-1.59,-2.47,;-1.59,-.93,;-2.92,-.16,;-3.25,1.35,;-.26,-3.24,;1.08,-2.47,;-.26,-4.78,;1.08,-4.01,)|
Structure:
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