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Target
Activin receptor type-1
Ligand
BDBM603863
Substrate
n/a
Meas. Tech.
Luciferase Reporter Gene Assay for ALK2 and TGFbeta Activity
IC50
2.00±n/a nM
Citation
 Yu, PB; Huang, W; Sanderson, PE; Jiang, J; Shamim, K; Zheng, W; Huang, X; Tawa, G; Lee, A; Alimardanov, A; Huang, J ALK2 inhibitors and methods for inhibiting BMP signaling US Patent  US11654147 Publication Date 5/23/2023 
Target
Name:
Activin receptor type-1
Synonyms:
2.7.11.30 | ACTR-I | ACVR1 | ACVR1_HUMAN | ACVRLK2 | ALK-2 | ALK2/ACVR1 | Activin receptor type I | Activin receptor-like kinase 2 | Activin receptor-like kinase 2 (ALK-2) | Activin receptor-like kinase 2 (ALK2/ACVR1) | Q04771 | SKR1 | Serine/threonine-protein kinase receptor R1 | TGF-B superfamily receptor type I | TSR-I
Type:
n/a
Mol. Mass.:
57158.32
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
509
Sequence:
MVDGVMILPVLIMIALPSPSMEDEKPKVNPKLYMCVCEGLSCGNEDHCEGQQCFSSLSINDGFHVYQKGCFQVYEQGKMTCKTPPSPGQAVECCQGDWCNRNITAQLPTKGKSFPGTQNFHLEVGLIILSVVFAVCLLACLLGVALRKFKRRNQERLNPRDVEYGTIEGLITTNVGDSTLADLLDHSCTSGSGSGLPFLVQRTVARQITLLECVGKGRYGEVWRGSWQGENVAVKIFSSRDEKSWFRETELYNTVMLRHENILGFIASDMTSRHSSTQLWLITHYHEMGSLYDYLQLTTLDTVSCLRIVLSIASGLAHLHIEIFGTQGKPAIAHRDLKSKNILVKKNGQCCIADLGLAVMHSQSTNQLDVGNNPRVGTKRYMAPEVLDETIQVDCFDSYKRVDIWAFGLVLWEVARRMVSNGIVEDYKPPFYDVVPNDPSFEDMRKVVCVDQQRPNIPNRWFSDPTLTSLAKLMKECWYQNPSARLTALRIKKTLTKIDNSLDKLKTDC
  
Inhibitor
Name:
BDBM603863
Synonyms:
US11654147, Compound 313 | US11654147, Compound 339
Type:
Small organic molecule
Emp. Form.:
C19H23N7
Mol. Mass.:
349.4328
SMILES:
CN1CCN(CC1)C1CN(C1)c1cnc2c(cnn2c1)-c1ccncc1
Structure:
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