Reaction Details Report a problem with these data
Target
Fatty-acid amide hydrolase 1
Ligand
BDBM483666
Substrate
n/a
Meas. Tech.
In Vitro Competitive Activity-Based Protein Assay
IC50
550±n/a nM
Citation
 Grice, CA; Wiener, JJ; Weber, OD; Duncan, KK Pyrazole MAGL inhibitors US Patent  US11655217 Publication Date 5/23/2023 
Target
Name:
Fatty-acid amide hydrolase 1
Synonyms:
Anandamide amidohydrolase | Anandamide amidohydrolase 1 | FAAH | FAAH1 | FAAH1_HUMAN | Fatty Acid Amide Hydrolase (FAAH) | Fatty-acid amide hydrolase (FAAH) | Fatty-acid amide hydrolase 1 | Oleamide hydrolase 1
Type:
Protein
Mol. Mass.:
63071.19
Organism:
Homo sapiens (Human)
Description:
O00519
Residue:
579
Sequence:
MVQYELWAALPGASGVALACCFVAAAVALRWSGRRTARGAVVRARQRQRAGLENMDRAAQRFRLQNPDLDSEALLALPLPQLVQKLHSRELAPEAVLFTYVGKAWEVNKGTNCVTSYLADCETQLSQAPRQGLLYGVPVSLKECFTYKGQDSTLGLSLNEGVPAECDSVVVHVLKLQGAVPFVHTNVPQSMFSYDCSNPLFGQTVNPWKSSKSPGGSSGGEGALIGSGGSPLGLGTDIGGSIRFPSSFCGICGLKPTGNRLSKSGLKGCVYGQEAVRLSVGPMARDVESLALCLRALLCEDMFRLDPTVPPLPFREEVYTSSQPLRVGYYETDNYTMPSPAMRRAVLETKQSLEAAGHTLVPFLPSNIPHALETLSTGGLFSDGGHTFLQNFKGDFVDPCLGDLVSILKLPQWLKGLLAFLVKPLLPRLSAFLSNMKSRSAGKLWELQHEIEVYRKTVIAQWRALDLDVVLTPMLAPALDLNAPGRATGAVSYTMLYNCLDFPAGVVPVTTVTAEDEAQMEHYRGYFGDIWDKMLQKGMKKSVGLPVAVQCVALPWQEELCLRFMREVERLMTPEKQSS
  
Inhibitor
Name:
BDBM483666
Synonyms:
1-(4-(3-((5- (trifluoromethyl)- pyridin-2- yl)oxy)benzyl)- piperazine-1- carbonyl)- 1H-pyrazole-3- carboxylic acid | US10927105, Ex 61 | US11655217, Example 61
Type:
Small organic molecule
Emp. Form.:
C22H20F3N5O4
Mol. Mass.:
475.4205
SMILES:
OC(=O)c1ccn(n1)C(=O)N1CCN(Cc2cccc(Oc3ccc(cn3)C(F)(F)F)c2)CC1
Structure:
Search PDB for entries with ligand similarity: