Reaction Details Report a problem with these data
Target
Fatty-acid amide hydrolase 1
Ligand
BDBM483720
Substrate
n/a
Meas. Tech.
In Vitro Competitive Activity-Based Protein Assay
IC50
<100±n/a nM
Citation
 Grice, CA; Wiener, JJ; Weber, OD; Duncan, KK Pyrazole MAGL inhibitors US Patent  US11655217 Publication Date 5/23/2023 
Target
Name:
Fatty-acid amide hydrolase 1
Synonyms:
Anandamide amidohydrolase | Anandamide amidohydrolase 1 | FAAH | FAAH1 | FAAH1_HUMAN | Fatty Acid Amide Hydrolase (FAAH) | Fatty-acid amide hydrolase (FAAH) | Fatty-acid amide hydrolase 1 | Oleamide hydrolase 1
Type:
Protein
Mol. Mass.:
63071.19
Organism:
Homo sapiens (Human)
Description:
O00519
Residue:
579
Sequence:
MVQYELWAALPGASGVALACCFVAAAVALRWSGRRTARGAVVRARQRQRAGLENMDRAAQRFRLQNPDLDSEALLALPLPQLVQKLHSRELAPEAVLFTYVGKAWEVNKGTNCVTSYLADCETQLSQAPRQGLLYGVPVSLKECFTYKGQDSTLGLSLNEGVPAECDSVVVHVLKLQGAVPFVHTNVPQSMFSYDCSNPLFGQTVNPWKSSKSPGGSSGGEGALIGSGGSPLGLGTDIGGSIRFPSSFCGICGLKPTGNRLSKSGLKGCVYGQEAVRLSVGPMARDVESLALCLRALLCEDMFRLDPTVPPLPFREEVYTSSQPLRVGYYETDNYTMPSPAMRRAVLETKQSLEAAGHTLVPFLPSNIPHALETLSTGGLFSDGGHTFLQNFKGDFVDPCLGDLVSILKLPQWLKGLLAFLVKPLLPRLSAFLSNMKSRSAGKLWELQHEIEVYRKTVIAQWRALDLDVVLTPMLAPALDLNAPGRATGAVSYTMLYNCLDFPAGVVPVTTVTAEDEAQMEHYRGYFGDIWDKMLQKGMKKSVGLPVAVQCVALPWQEELCLRFMREVERLMTPEKQSS
  
Inhibitor
Name:
BDBM483720
Synonyms:
1-(cis-5-(methyl(2- (trifluoromethyl)- benzyl)amino)- octahydrocyclopenta- [c]pyrrole- 2-carbonyl)-1H- pyrazole-3- carboxamide | US10927105, Ex 204 | US11655217, Example 204
Type:
Small organic molecule
Emp. Form.:
C21H24F3N5O2
Mol. Mass.:
435.4428
SMILES:
CN(Cc1ccccc1C(F)(F)F)[C@H]1C[C@H]2CN(C[C@H]2C1)C(=O)n1ccc(n1)C(N)=O |r|
Structure:
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