Reaction Details Report a problem with these data
Target
Granzyme B
Ligand
BDBM605110
Substrate
n/a
Meas. Tech.
Biochemical Assay
IC50
150±n/a nM
Citation
 Bilcer, GM; Kelly, TA Granzyme B directed imaging and therapy US Patent  US11667645 Publication Date 6/6/2023 
Target
Name:
Granzyme B
Synonyms:
CGL1 | CSPB | CTLA1 | GRAB_HUMAN | GRB | GZMB
Type:
PROTEIN
Mol. Mass.:
27735.56
Organism:
Homo sapiens (Human)
Description:
ChEMBL_469245
Residue:
247
Sequence:
MQPILLLLAFLLLPRADAGEIIGGHEAKPHSRPYMAYLMIWDQKSLKRCGGFLIRDDFVLTAAHCWGSSINVTLGAHNIKEQEPTQQFIPVKRPIPHPAYNPKNFSNDIMLLQLERKAKRTRAVQPLRLPSNKAQVKPGQTCSVAGWGQTAPLGKHSHTLQEVKMTVQEDRKCESDLRHYYDSTIELCVGDPEIKKTSFKGDSGGPLVCNKVAQGIVSYGRNNGMPPRACTKVSSFVHWIKKTMKRY
  
Inhibitor
Name:
BDBM605110
Synonyms:
(2S,5S)-5-((2S,3R)-2-Benzoylamino-3- methyl-pentanoylamino)-4-oxo- 1,2,4,5,6,7-hexahydro-azepino[3,2,1- hi]indole-2-carboxylic acid (1H- [1,2,3]triazol-4-ylmethyl)-amide | US11667645, Compound C053
Type:
Small organic molecule
Emp. Form.:
C29H33N7O4
Mol. Mass.:
543.6168
SMILES:
CC[C@@H](C)[C@H](NC(=O)c1ccccc1)C(=O)N[C@H]1CCc2cccc3C[C@H](N(c23)C1=O)C(=O)NCc1c[nH]nn1 |r|
Structure:
Search PDB for entries with ligand similarity: