Reaction Details Report a problem with these data
Target
Granzyme B
Ligand
BDBM605113
Substrate
n/a
Meas. Tech.
Biochemical Assay
IC50
150±n/a nM
Citation
 Bilcer, GM; Kelly, TA Granzyme B directed imaging and therapy US Patent  US11667645 Publication Date 6/6/2023 
Target
Name:
Granzyme B
Synonyms:
CGL1 | CSPB | CTLA1 | GRAB_HUMAN | GRB | GZMB
Type:
PROTEIN
Mol. Mass.:
27735.56
Organism:
Homo sapiens (Human)
Description:
ChEMBL_469245
Residue:
247
Sequence:
MQPILLLLAFLLLPRADAGEIIGGHEAKPHSRPYMAYLMIWDQKSLKRCGGFLIRDDFVLTAAHCWGSSINVTLGAHNIKEQEPTQQFIPVKRPIPHPAYNPKNFSNDIMLLQLERKAKRTRAVQPLRLPSNKAQVKPGQTCSVAGWGQTAPLGKHSHTLQEVKMTVQEDRKCESDLRHYYDSTIELCVGDPEIKKTSFKGDSGGPLVCNKVAQGIVSYGRNNGMPPRACTKVSSFVHWIKKTMKRY
  
Inhibitor
Name:
BDBM605113
Synonyms:
(2S,5S)-5-{(S)-2-[2-(2-Fluoro-ethoxy)- acetylamino]-3-methyl-butyrylamino}- 4-oxo-1,2,4,5,6,7-hexahydro- azepino[3,2,1-hi]indole-2-carboxylic acid (1H-[1,2,3]triazol-4-ylmethyl)- amide | US11667645, Compound C056
Type:
Small organic molecule
Emp. Form.:
C25H32FN7O5
Mol. Mass.:
529.5639
SMILES:
CC(C)[C@H](NC(=O)COCCF)C(=O)N[C@H]1CCc2cccc3C[C@H](N(c23)C1=O)C(=O)NCc1c[nH]nn1 |r|
Structure:
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