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Target
Granzyme B
Ligand
BDBM605118
Substrate
n/a
Meas. Tech.
Biochemical Assay
IC50
150±n/a nM
Citation
 Bilcer, GM; Kelly, TA Granzyme B directed imaging and therapy US Patent  US11667645 Publication Date 6/6/2023 
Target
Name:
Granzyme B
Synonyms:
CGL1 | CSPB | CTLA1 | GRAB_HUMAN | GRB | GZMB
Type:
PROTEIN
Mol. Mass.:
27735.56
Organism:
Homo sapiens (Human)
Description:
ChEMBL_469245
Residue:
247
Sequence:
MQPILLLLAFLLLPRADAGEIIGGHEAKPHSRPYMAYLMIWDQKSLKRCGGFLIRDDFVLTAAHCWGSSINVTLGAHNIKEQEPTQQFIPVKRPIPHPAYNPKNFSNDIMLLQLERKAKRTRAVQPLRLPSNKAQVKPGQTCSVAGWGQTAPLGKHSHTLQEVKMTVQEDRKCESDLRHYYDSTIELCVGDPEIKKTSFKGDSGGPLVCNKVAQGIVSYGRNNGMPPRACTKVSSFVHWIKKTMKRY
  
Inhibitor
Name:
BDBM605118
Synonyms:
(2S,5S)-5-[(2S,3S)-2-(3-Methoxy- benzoylamino)-3-methyl- pentanoylamino]-4-oxo-1,2,4,5,6,7- hexahydro-azepino[3,2,1-hi]indole-2- carboxylic acid(1H-[1,2,3]triazol-4- ylmethyl)-amide | US11667645, Compound C061
Type:
Small organic molecule
Emp. Form.:
C30H35N7O5
Mol. Mass.:
573.6428
SMILES:
CC[C@H](C)[C@H](NC(=O)c1cccc(OC)c1)C(=O)N[C@H]1CCc2cccc3C[C@H](N(c23)C1=O)C(=O)NCc1c[nH]nn1 |r|
Structure:
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