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Target
Mitogen-activated protein kinase kinase kinase kinase 1
Ligand
BDBM606199
Substrate
n/a
Meas. Tech.
Biochemical Selectivity Kinase Assay
Ki
<0.050±n/a nM
Citation
 Barber, J; Cho-Schultz, S; Del Bel, ML; Gallego, RA; He, M; Jalaie, M; Kania, RS; McTigue, MA; Nair, SK; Schmitt, AD; Tuttle, JB; Zhou, D; Zhou, R Azalactam compounds as HPK1 inhibitors US Patent  US11684616 Publication Date 6/27/2023 
Target
Name:
Mitogen-activated protein kinase kinase kinase kinase 1
Synonyms:
HPK1 | M4K1_HUMAN | MAP4K1
Type:
PROTEIN
Mol. Mass.:
91316.07
Organism:
Homo sapiens (Human)
Description:
ChEMBL_586597
Residue:
833
Sequence:
MDVVDPDIFNRDPRDHYDLLQRLGGGTYGEVFKARDKVSGDLVALKMVKMEPDDDVSTLQKEILILKTCRHANIVAYHGSYLWLQKLWICMEFCGAGSLQDIYQVTGSLSELQISYVCREVLQGLAYLHSQKKIHRDIKGANILINDAGEVRLADFGISAQIGATLARRLSFIGTPYWMAPEVAAVALKGGYNELCDIWSLGITAIELAELQPPLFDVHPLRVLFLMTKSGYQPPRLKEKGKWSAAFHNFIKVTLTKSPKKRPSATKMLSHQLVSQPGLNRGLILDLLDKLKNPGKGPSIGDIEDEEPELPPAIPRRIRSTHRSSSLGIPDADCCRRHMEFRKLRGMETRPPANTARLQPPRDLRSSSPRKQLSESSDDDYDDVDIPTPAEDTPPPLPPKPKFRSPSDEGPGSMGDDGQLSPGVLVRCASGPPPNSPRPGPPPSTSSPHLTAHSEPSLWNPPSRELDKPPLLPPKKEKMKRKGCALLVKLFNGCPLRIHSTAAWTHPSTKDQHLLLGAEEGIFILNRNDQEATLEMLFPSRTTWVYSINNVLMSLSGKTPHLYSHSILGLLERKETRAGNPIAHISPHRLLARKNMVSTKIQDTKGCRACCVAEGASSGGPFLCGALETSVVLLQWYQPMNKFLLVRQVLFPLPTPLSVFALLTGPGSELPAVCIGVSPGRPGKSVLFHTVRFGALSCWLGEMSTEHRGPVQVTQVEEDMVMVLMDGSVKLVTPEGSPVRGLRTPEIPMTEAVEAVAMVGGQLQAFWKHGVQVWALGSDQLLQELRDPTLTFRLLGSPRLECSGTISPHCNLLLPGSSNSPASASRVAGITGL
  
Inhibitor
Name:
BDBM606199
Synonyms:
2-{6-[(5R)-5- (fluoromethyl)- 6,7-dihydro-5H- pyrrolo[2,1- c][1,2,4]triazol-3- yl]pyridin-2-yl}- 4-[(methyl- amino)methyl]- 6-[methyl (propan-2-yl) amino]-2,3- dihydro-1H- pyrrolo[3,4-c] pyridin-1-one | US11684616, Example 205
Type:
Small organic molecule
Emp. Form.:
C24H29FN8O
Mol. Mass.:
464.5385
SMILES:
CNCc1nc(cc2C(=O)N(Cc12)c1cccc(n1)-c1nnc2CC[C@H](CF)n12)N(C)C(C)C |r|
Structure:
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