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Target
Histone acetyltransferase KAT5
Ligand
BDBM606452
Substrate
n/a
Meas. Tech.
KAT-5 Enzyme Assay
IC50
<10000±n/a nM
Citation
 Harvey, DM; Campbell, JE; Duncan, KW MYST family histone acetyltransferase inhibitors US Patent  US11685732 Publication Date 6/27/2023 
Target
Name:
Histone acetyltransferase KAT5
Synonyms:
HTATIP | KAT5 | KAT5_HUMAN | TIP60
Type:
PROTEIN
Mol. Mass.:
58595.98
Organism:
Homo sapiens (Human)
Description:
ChEMBL_796787
Residue:
513
Sequence:
MAEVGEIIEGCRLPVLRRNQDNEDEWPLAEILSVKDISGRKLFYVHYIDFNKRLDEWVTHERLDLKKIQFPKKEAKTPTKNGLPGSRPGSPEREVPASAQASGKTLPIPVQITLRFNLPKEREAIPGGEPDQPLSSSSCLQPNHRSTKRKVEVVSPATPVPSETAPASVFPQNGAARRAVAAQPGRKRKSNCLGTDEDSQDSSDGIPSAPRMTGSLVSDRSHDDIVTRMKNIECIELGRHRLKPWYFSPYPQELTTLPVLYLCEFCLKYGRSLKCLQRHLTKCDLRHPPGNEIYRKGTISFFEIDGRKNKSYSQNLCLLAKCFLDHKTLYYDTDPFLFYVMTEYDCKGFHIVGYFSKEKESTEDYNVACILTLPPYQRRGYGKLLIEFSYELSKVEGKTGTPEKPLSDLGLLSYRSYWSQTILEILMGLKSESGERPQITINEISEITSIKKEDVISTLQYLNLINYYKGQYILTLSEDIVDGHERAMLKRLLRIDSKCLHFTPKDWSKRGKW
  
Inhibitor
Name:
BDBM606452
Synonyms:
US11685732, Compound I-99
Type:
Small organic molecule
Emp. Form.:
C20H25ClFN5O4S
Mol. Mass.:
485.96
SMILES:
CC(=O)NC1CCCC(CS(=O)(=O)NNC(=O)c2cc(cc(Cl)c2F)-c2cn(C)cn2)C1
Structure:
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