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Target
Bromodomain-containing protein 4 [42-168]
Ligand
BDBM310874
Substrate
n/a
Meas. Tech.
BRD4 AlphaLisa Binding Assay
IC50
110±n/a nM
Citation
 Albrecht, BK; Bellon, SF; Burdick, DJ; Cote, A; Crawford, T; Dakin, LA; Hsiao-Wei Tsui, V; Hewitt, MC; LeBlanc, Y; Magnuson, SR; Nasveschuk, CG; Romero, AF; Tang, Y; Taylor, AM; Wang, S Therapeutic compounds and uses thereof US Patent  US10150767 Publication Date 12/11/2018 
Target
Name:
Bromodomain-containing protein 4 [42-168]
Synonyms:
BRD4 | BRD4 BD1 (aa 42-168) | BRD4_HUMAN | Bromodomain-containing protein 4 Bromo Domain 1 | HUNK1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
15054.68
Organism:
Homo sapiens (Human)
Description:
O60885[42-168]
Residue:
127
Sequence:
STNPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKINELPTEE
  
Inhibitor
Name:
BDBM310874
Synonyms:
US10150767, Example 4 | tert-butyl 6-(6-methyl-7-oxo-1H-pyrrolo[2,3-c]pyridin-4-yl)-3,4-dihydro-2H-quinoline-1-carboxylate
Type:
Small organic molecule
Emp. Form.:
C22H25N3O3
Mol. Mass.:
379.4522
SMILES:
Cn1cc(-c2ccc3N(CCCc3c2)C(=O)OC(C)(C)C)c2cc[nH]c2c1=O
Structure:
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