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Target
Bromodomain-containing protein 4 [42-168]
Ligand
BDBM310880
Substrate
n/a
Meas. Tech.
BRD4 AlphaLisa Binding Assay
IC50
58.0±n/a nM
Citation
 Albrecht, BK; Bellon, SF; Burdick, DJ; Cote, A; Crawford, T; Dakin, LA; Hsiao-Wei Tsui, V; Hewitt, MC; LeBlanc, Y; Magnuson, SR; Nasveschuk, CG; Romero, AF; Tang, Y; Taylor, AM; Wang, S Therapeutic compounds and uses thereof US Patent  US10150767 Publication Date 12/11/2018 
Target
Name:
Bromodomain-containing protein 4 [42-168]
Synonyms:
BRD4 | BRD4 BD1 (aa 42-168) | BRD4_HUMAN | Bromodomain-containing protein 4 Bromo Domain 1 | HUNK1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
15054.68
Organism:
Homo sapiens (Human)
Description:
O60885[42-168]
Residue:
127
Sequence:
STNPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKINELPTEE
  
Inhibitor
Name:
BDBM310880
Synonyms:
7-(6-methyl-7-oxo-1H-pyrrolo[2,3-c]pyridin-4-yl)-4-(2-thienyl)-1,3,4,5-tetrahydro-1,5-benzodiazepin-2-one | US10150767, Example 17
Type:
Small organic molecule
Emp. Form.:
C21H18N4O2S
Mol. Mass.:
390.458
SMILES:
Cn1cc(-c2ccc3NC(=O)CC(Nc3c2)c2cccs2)c2cc[nH]c2c1=O
Structure:
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