Reaction Details Report a problem with these data
Target
Transcription initiation factor TFIID subunit 1 [1504-1635]
Ligand
BDBM310915
Substrate
n/a
Meas. Tech.
TAF1-BD2 TR-FRET Binding Assay
IC50
63.0±n/a nM
Citation
 Albrecht, BK; Bellon, SF; Burdick, DJ; Cote, A; Crawford, T; Dakin, LA; Hsiao-Wei Tsui, V; Hewitt, MC; LeBlanc, Y; Magnuson, SR; Nasveschuk, CG; Romero, AF; Tang, Y; Taylor, AM; Wang, S Therapeutic compounds and uses thereof US Patent  US10150767 Publication Date 12/11/2018 
Target
Name:
Transcription initiation factor TFIID subunit 1 [1504-1635]
Synonyms:
BA2R | CCG1 | CCGS | TAF1 | TAF1-BD2 (11 1504-1635) | TAF1-BD2 (aa 1504-1635) | TAF1_HUMAN | TAF2A
Type:
Enzyme Catalytic Domain
Mol. Mass.:
15296.09
Organism:
Homo sapiens (Human)
Description:
P21675[1504-1635]
Residue:
132
Sequence:
QVAFSFILDNIVTQKMMAVPDSWPFHHPVNKKFVPDYYKVIVNPMDLETIRKNISKHKYQSRESFLDDVNLILANSVKYNGPESQYTKTAQEIVNVCYQTLTEYDEHLTQLEKDICTAKEAALEEAELESLD
  
Inhibitor
Name:
BDBM310915
Synonyms:
N-benzyl-4-(6-methyl-7-oxo-1H-pyrrolo[2,3-c]pyridin-4-yl)benzamide | US10150767, Example 37
Type:
Small organic molecule
Emp. Form.:
C22H19N3O2
Mol. Mass.:
357.4052
SMILES:
Cn1cc(-c2cccc(c2)C(=O)NCc2ccccc2)c2cc[nH]c2c1=O
Structure:
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