Reaction Details Report a problem with these data
Target
cAMP-specific 3',5'-cyclic phosphodiesterase 7B
Ligand
BDBM607116
Substrate
n/a
Meas. Tech.
Enzymatic Assay
IC50
<10.00±n/a nM
Citation
 Santora, VJ; Chen, M; Chung, D Substituted benzoxazole and benzofuran compounds as PDE7 inhibitors US Patent  US11685745 Publication Date 6/27/2023 
Target
Name:
cAMP-specific 3',5'-cyclic phosphodiesterase 7B
Synonyms:
3',5'-cyclic phosphodiesterase | PDE7B | PDE7B_HUMAN | Phosphodiesterase 7B | Phosphodiesterase 7B (PDE7B) | cAMP-specific 3',5'-cyclic phosphodiesterase 7B
Type:
Enzyme
Mol. Mass.:
51842.76
Organism:
Homo sapiens (Human)
Description:
Q9NP56
Residue:
450
Sequence:
MSCLMVERCGEILFENPDQNAKCVCMLGDIRLRGQTGVRAERRGSYPFIDFRLLNSTTYSGEIGTKKKVKRLLSFQRYFHASRLLRGIIPQAPLHLLDEDYLGQARHMLSKVGMWDFDIFLFDRLTNGNSLVTLLCHLFNTHGLIHHFKLDMVTLHRFLVMVQEDYHSQNPYHNAVHAADVTQAMHCYLKEPKLASFLTPLDIMLGLLAAAAHDVDHPGVNQPFLIKTNHHLANLYQNMSVLENHHWRSTIGMLRESRLLAHLPKEMTQDIEQQLGSLILATDINRQNEFLTRLKAHLHNKDLRLEDAQDRHFMLQIALKCADICNPCRIWEMSKQWSERVCEEFYRQGELEQKFELEISPLCNQQKDSIPSIQIGFMSYIVEPLFREWAHFTGNSTLSENMLGHLAHNKAQWKSLLPRQHRSRGSSGSGPDHDHAGQGTESEEQEGDSP
  
Inhibitor
Name:
BDBM607116
Synonyms:
US11685745, Example 336
Type:
Small organic molecule
Emp. Form.:
C22H22ClF2N3O3
Mol. Mass.:
449.878
SMILES:
FC1(F)[C@H]2CC(C[C@@H]12)NC(=O)c1cc2cc(Cl)c3NC(=O)NC4(CCCCC4)c3c2o1 |r,$;;;;;;;;;;;;;;;;;;;;O;;;;;;;;;;$|
Structure:
Search PDB for entries with ligand similarity: