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Target
Tyrosine-protein phosphatase non-receptor type 11
Ligand
BDBM608430
Substrate
n/a
Meas. Tech.
SHP2 Biochemical Assay
IC50
200±n/a nM
Citation
 Jorand-Lebrun, C; Boivin, R; Mochalkin, I; Johnson, T; Linde, N; Musch, D; Kumar, D Carboxamide-pyrimidine derivatives as SHP2 antagonists US Patent  US11696916 Publication Date 7/11/2023 
Target
Name:
Tyrosine-protein phosphatase non-receptor type 11
Synonyms:
3.1.3.48 | PTN11_HUMAN | PTP-1D | PTP-2C | PTP2C | PTPN11 | Protein Tyrosine Phosphatase PPN11/Shp2 | Protein tyrosine phosphatase (PTP) Shp2 | Protein-Tyrosine Phosphatase SHP-2 | Protein-tyrosine phosphatase 1D | Protein-tyrosine phosphatase 2C | SH-PTP2 | SH-PTP3 | SHP-2 | SHP2 | SHPTP2 | Src homology phosphatase 2 (SHP-2) | Tyrosine-protein phosphatase non-receptor type 11 (PTPN11) | Tyrosine-protein phosphatase non-receptor type 11 (SHP-2) | Tyrosine-protein phosphatase non-receptor type 11 (SHP2)
Type:
Protein phosphatase
Mol. Mass.:
68443.59
Organism:
Homo sapiens (Human)
Description:
Q06124
Residue:
593
Sequence:
MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAELVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR
  
Inhibitor
Name:
BDBM608430
Synonyms:
2-[(4-Amino-cyclohexyl)-methyl- amino]-5-(2,3-dichloro-phenyl)-6- methyl-pyrimidine-4-carboxylic acid amide | US11696916, Compound 32
Type:
Small organic molecule
Emp. Form.:
C19H23Cl2N5O
Mol. Mass.:
408.325
SMILES:
CN(C1CCC(N)CC1)c1nc(C)c(-c2cccc(Cl)c2Cl)c(n1)C(N)=O |(1.57,-.87,;1.57,.67,;3.05,1.07,;3.82,-.27,;5.36,-.27,;6.13,1.07,;7.67,1.07,;5.36,2.4,;3.82,2.4,;.03,.67,;-.74,2,;-2.28,2,;-3.05,3.33,;-3.05,.67,;-4.59,.67,;-5.36,-.67,;-6.9,-.67,;-7.67,.67,;-6.9,2,;-7.67,3.33,;-5.36,2,;-4.59,3.33,;-2.28,-.67,;-.74,-.67,;-3.05,-2,;-2.28,-3.33,;-4.59,-2,)|
Structure:
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