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Target
Tyrosine-protein phosphatase non-receptor type 11
Ligand
BDBM503386
Substrate
n/a
Meas. Tech.
SHP2 Biochemical Assay
IC50
410±n/a nM
Citation
 Jorand-Lebrun, C; Boivin, R; Mochalkin, I; Johnson, T; Linde, N; Musch, D; Kumar, D Carboxamide-pyrimidine derivatives as SHP2 antagonists US Patent  US11696916 Publication Date 7/11/2023 
Target
Name:
Tyrosine-protein phosphatase non-receptor type 11
Synonyms:
3.1.3.48 | PTN11_HUMAN | PTP-1D | PTP-2C | PTP2C | PTPN11 | Protein Tyrosine Phosphatase PPN11/Shp2 | Protein tyrosine phosphatase (PTP) Shp2 | Protein-Tyrosine Phosphatase SHP-2 | Protein-tyrosine phosphatase 1D | Protein-tyrosine phosphatase 2C | SH-PTP2 | SH-PTP3 | SHP-2 | SHP2 | SHPTP2 | Src homology phosphatase 2 (SHP-2) | Tyrosine-protein phosphatase non-receptor type 11 (PTPN11) | Tyrosine-protein phosphatase non-receptor type 11 (SHP-2) | Tyrosine-protein phosphatase non-receptor type 11 (SHP2)
Type:
Protein phosphatase
Mol. Mass.:
68443.59
Organism:
Homo sapiens (Human)
Description:
Q06124
Residue:
593
Sequence:
MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAELVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR
  
Inhibitor
Name:
BDBM503386
Synonyms:
(4M)-2-{[(1R,3S)-3- aminocyclohexyl]amino}-5-(2,3- dichlorophenyl)-6- methylpyrimidine-4-carboxamide | US11033547, Compound 88 | US11033547, Compound 89 | US11696916, Compound 89
Type:
Small organic molecule
Emp. Form.:
C18H21Cl2N5O
Mol. Mass.:
394.298
SMILES:
Cc1nc(N[C@@H]2CCC[C@H](N)C2)nc(C(N)=O)c1-c1cccc(Cl)c1Cl |r,wD:5.4,9.9,(-2.31,2.67,;-1.54,1.33,;,1.33,;.77,,;2.31,,;3.08,1.33,;2.31,2.67,;3.08,4,;4.62,4,;5.39,2.67,;6.93,2.67,;4.62,1.33,;,-1.33,;-1.54,-1.33,;-2.31,-2.67,;-1.54,-4,;-3.85,-2.67,;-2.31,,;-3.85,,;-4.62,-1.33,;-6.16,-1.33,;-6.93,,;-6.16,1.33,;-6.93,2.67,;-4.62,1.33,;-3.85,2.67,)|
Structure:
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