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Target
Tyrosine-protein phosphatase non-receptor type 11
Ligand
BDBM608518
Substrate
n/a
Meas. Tech.
SHP2 Biochemical Assay
IC50
15.0±n/a nM
Citation
 Jorand-Lebrun, C; Boivin, R; Mochalkin, I; Johnson, T; Linde, N; Musch, D; Kumar, D Carboxamide-pyrimidine derivatives as SHP2 antagonists US Patent  US11696916 Publication Date 7/11/2023 
Target
Name:
Tyrosine-protein phosphatase non-receptor type 11
Synonyms:
3.1.3.48 | PTN11_HUMAN | PTP-1D | PTP-2C | PTP2C | PTPN11 | Protein Tyrosine Phosphatase PPN11/Shp2 | Protein tyrosine phosphatase (PTP) Shp2 | Protein-Tyrosine Phosphatase SHP-2 | Protein-tyrosine phosphatase 1D | Protein-tyrosine phosphatase 2C | SH-PTP2 | SH-PTP3 | SHP-2 | SHP2 | SHPTP2 | Src homology phosphatase 2 (SHP-2) | Tyrosine-protein phosphatase non-receptor type 11 (PTPN11) | Tyrosine-protein phosphatase non-receptor type 11 (SHP-2) | Tyrosine-protein phosphatase non-receptor type 11 (SHP2)
Type:
Protein phosphatase
Mol. Mass.:
68443.59
Organism:
Homo sapiens (Human)
Description:
Q06124
Residue:
593
Sequence:
MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAELVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR
  
Inhibitor
Name:
BDBM608518
Synonyms:
6-amino-2-[(3R)-3-amino-3H-spiro[1- benzofuran-2,4'-piperidin]-1'-yl]-5-(2,3- dichlorophenyl)pyrimidine-4- carboxamide | US11696916, Compound 123
Type:
Small organic molecule
Emp. Form.:
C23H22Cl2N6O2
Mol. Mass.:
485.366
SMILES:
N[C@@H]1c2ccccc2OC11CCN(CC1)c1nc(N)c(-c2cccc(Cl)c2Cl)c(n1)C(N)=O |r,wD:1.0,(5.14,-.68,;4.37,-2.02,;5.4,-3.16,;6.94,-3.16,;7.71,-4.49,;6.94,-5.83,;5.4,-5.83,;4.63,-4.49,;3.12,-4.17,;2.96,-2.64,;1.63,-3.41,;.29,-2.64,;.29,-1.1,;1.63,-.33,;2.96,-1.1,;-1.04,-.33,;-1.04,1.21,;-2.37,1.98,;-2.37,3.52,;-3.71,1.21,;-5.04,1.98,;-6.37,1.21,;-7.71,1.98,;-7.71,3.52,;-6.37,4.29,;-6.37,5.83,;-5.04,3.52,;-3.71,4.29,;-3.71,-.33,;-2.37,-1.1,;-5.04,-1.1,;-5.04,-2.64,;-6.37,-.33,)|
Structure:
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