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Target
Tyrosine-protein phosphatase non-receptor type 11
Ligand
BDBM608520
Substrate
n/a
Meas. Tech.
SHP2 Biochemical Assay
IC50
530±n/a nM
Citation
 Jorand-Lebrun, C; Boivin, R; Mochalkin, I; Johnson, T; Linde, N; Musch, D; Kumar, D Carboxamide-pyrimidine derivatives as SHP2 antagonists US Patent  US11696916 Publication Date 7/11/2023 
Target
Name:
Tyrosine-protein phosphatase non-receptor type 11
Synonyms:
3.1.3.48 | PTN11_HUMAN | PTP-1D | PTP-2C | PTP2C | PTPN11 | Protein Tyrosine Phosphatase PPN11/Shp2 | Protein tyrosine phosphatase (PTP) Shp2 | Protein-Tyrosine Phosphatase SHP-2 | Protein-tyrosine phosphatase 1D | Protein-tyrosine phosphatase 2C | SH-PTP2 | SH-PTP3 | SHP-2 | SHP2 | SHPTP2 | Src homology phosphatase 2 (SHP-2) | Tyrosine-protein phosphatase non-receptor type 11 (PTPN11) | Tyrosine-protein phosphatase non-receptor type 11 (SHP-2) | Tyrosine-protein phosphatase non-receptor type 11 (SHP2)
Type:
Protein phosphatase
Mol. Mass.:
68443.59
Organism:
Homo sapiens (Human)
Description:
Q06124
Residue:
593
Sequence:
MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAELVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR
  
Inhibitor
Name:
BDBM608520
Synonyms:
(4M)-2-[(3S)-3-amino-3H-spiro[furo[2,3- b]pyridine-2,4'-piperidin]-1'-yl]-5-(2,3- dichlorophenyl)-6-methylpyrimidine-4- carboxamide | US11696916, Compound 125 | US11696916, Compound 127
Type:
Small organic molecule
Emp. Form.:
C23H22Cl2N6O2
Mol. Mass.:
485.366
SMILES:
Cc1nc(nc(C(N)=O)c1-c1cccc(Cl)c1Cl)N1CCC2(CC1)Oc1ncccc1[C@@H]2N |r,wU:31.36,(-3.84,3.33,;-3.07,2,;-1.53,2,;-.76,.67,;-1.53,-.67,;-3.07,-.67,;-3.84,-2,;-3.07,-3.33,;-5.38,-2,;-3.84,.67,;-5.82,.67,;-6.59,-.67,;-8.13,-.67,;-8.9,.67,;-8.13,2,;-8.9,3.33,;-6.59,2,;-5.82,3.33,;.78,.67,;1.55,-.67,;3.09,-.67,;3.86,.67,;3.09,2,;1.55,2,;4.77,-.58,;6.23,-.1,;7.57,-.87,;8.9,-.1,;8.9,1.44,;7.57,2.21,;6.23,1.44,;4.77,1.91,;4,3.25,)|
Structure:
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