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Target
Tyrosine-protein phosphatase non-receptor type 11
Ligand
BDBM608523
Substrate
n/a
Meas. Tech.
SHP2 Biochemical Assay
IC50
330±n/a nM
Citation
 Jorand-Lebrun, C; Boivin, R; Mochalkin, I; Johnson, T; Linde, N; Musch, D; Kumar, D Carboxamide-pyrimidine derivatives as SHP2 antagonists US Patent  US11696916 Publication Date 7/11/2023 
Target
Name:
Tyrosine-protein phosphatase non-receptor type 11
Synonyms:
3.1.3.48 | PTN11_HUMAN | PTP-1D | PTP-2C | PTP2C | PTPN11 | Protein Tyrosine Phosphatase PPN11/Shp2 | Protein tyrosine phosphatase (PTP) Shp2 | Protein-Tyrosine Phosphatase SHP-2 | Protein-tyrosine phosphatase 1D | Protein-tyrosine phosphatase 2C | SH-PTP2 | SH-PTP3 | SHP-2 | SHP2 | SHPTP2 | Src homology phosphatase 2 (SHP-2) | Tyrosine-protein phosphatase non-receptor type 11 (PTPN11) | Tyrosine-protein phosphatase non-receptor type 11 (SHP-2) | Tyrosine-protein phosphatase non-receptor type 11 (SHP2)
Type:
Protein phosphatase
Mol. Mass.:
68443.59
Organism:
Homo sapiens (Human)
Description:
Q06124
Residue:
593
Sequence:
MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAELVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR
  
Inhibitor
Name:
BDBM608523
Synonyms:
(4P)-6-amino-2-[(3R)-3-amino-3H- spiro[furo[2,3-b]pyridine-2,4'-piperidin]- 1'-yl]-5-(2,3-dichlorophenyl)pyrimidine- 4-carboxamide | US11696916, Compound 128 | US11696916, Compound 129
Type:
Small organic molecule
Emp. Form.:
C22H21Cl2N7O2
Mol. Mass.:
486.354
SMILES:
N[C@@H]1c2cccnc2OC11CCN(CC1)c1nc(N)c(-c2cccc(Cl)c2Cl)c(n1)C(N)=O |r,wD:1.0,(4,3.22,;4.77,1.89,;6.23,1.41,;7.57,2.18,;8.9,1.41,;8.9,-.13,;7.57,-.9,;6.23,-.13,;4.77,-.6,;3.86,.64,;3.09,-.69,;1.55,-.69,;.78,.64,;1.55,1.98,;3.09,1.98,;-.76,.64,;-1.53,1.98,;-3.07,1.98,;-3.84,3.31,;-3.84,.64,;-5.82,.64,;-6.59,-.69,;-8.13,-.69,;-8.9,.64,;-8.13,1.98,;-8.9,3.31,;-6.59,1.98,;-7.14,3.36,;-3.07,-.69,;-1.53,-.69,;-3.84,-2.02,;-3.07,-3.36,;-5.38,-2.02,)|
Structure:
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