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Target
Tyrosine-protein phosphatase non-receptor type 11
Ligand
BDBM497021
Substrate
n/a
Meas. Tech.
SHP2 Biochemical Assay
IC50
3000±n/a nM
Citation
 Jorand-Lebrun, C; Boivin, R; Johnson, T; Wang, Y; Xiao, Y; Chen, X; Linde, N; Musch, D; Kumar, D Pyrimidinone derivatives as SHP2 antagonists US Patent  US11702392 Publication Date 7/18/2023 
Target
Name:
Tyrosine-protein phosphatase non-receptor type 11
Synonyms:
3.1.3.48 | PTN11_HUMAN | PTP-1D | PTP-2C | PTP2C | PTPN11 | Protein Tyrosine Phosphatase PPN11/Shp2 | Protein tyrosine phosphatase (PTP) Shp2 | Protein-Tyrosine Phosphatase SHP-2 | Protein-tyrosine phosphatase 1D | Protein-tyrosine phosphatase 2C | SH-PTP2 | SH-PTP3 | SHP-2 | SHP2 | SHPTP2 | Src homology phosphatase 2 (SHP-2) | Tyrosine-protein phosphatase non-receptor type 11 (PTPN11) | Tyrosine-protein phosphatase non-receptor type 11 (SHP-2) | Tyrosine-protein phosphatase non-receptor type 11 (SHP2)
Type:
Protein phosphatase
Mol. Mass.:
68443.59
Organism:
Homo sapiens (Human)
Description:
Q06124
Residue:
593
Sequence:
MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAELVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR
  
Inhibitor
Name:
BDBM497021
Synonyms:
US11001561, Compound 17 | US11702392, Compound 17
Type:
Small organic molecule
Emp. Form.:
C18H20Cl2F2N4O
Mol. Mass.:
417.28
SMILES:
CC1(CN)CCN(CC1)c1cc(=O)n(-c2cccc(Cl)c2Cl)c(n1)C(F)F |(5.07,-4.21,;4.67,-2.72,;6,-1.95,;7.34,-2.72,;3.33,-3.49,;2,-2.72,;2,-1.18,;3.33,-.41,;4.67,-1.18,;.67,-.41,;-.67,-1.18,;-2,-.41,;-3.33,-1.18,;-2,1.13,;-3.33,1.9,;-3.33,3.44,;-4.67,4.21,;-6,3.44,;-6,1.9,;-7.34,1.13,;-4.67,1.13,;-4.67,-.41,;-.67,1.9,;.67,1.13,;-.67,3.44,;-2,4.21,;.67,4.21,)|
Structure:
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