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Target
Interleukin-1 receptor-associated kinase 4
Ligand
BDBM50239489
Substrate
n/a
Meas. Tech.
IRAK4 Enzymatic DELFIA Assay, Protocol A
IC50
7.60±n/a nM
Citation
 Trzupek, JD; Lee, KL; Bunnage, ME; Han, S; Hepworth, D; Lovering, FE; Mathias, JP; Papaioannou, N; Pierce, BS; Strohbach, JW; Wright, SW; Zapf, CW; Gavrin, LK; Lee, A; Anderson, DR; Curran, KJ; Dehnhardt, CM; Saiah, E; Goldberg, JA; Wang, X; Huang, H; Vargas, R; Lowe, MD; Patny, A Bicyclic-fused heteroaryl or aryl compounds US Patent  US11702424 Publication Date 7/18/2023 
Target
Name:
Interleukin-1 receptor-associated kinase 4
Synonyms:
IRAK-4 | IRAK4 | IRAK4_HUMAN | Interleukin-1 receptor-associated kinase 4 (IRAK-4) | Interleukin-1 receptor-associated kinase 4 (IRAK4) | Renal carcinoma antigen NY-REN-64
Type:
Protein
Mol. Mass.:
51519.08
Organism:
Homo sapiens (Human)
Description:
Q9NWZ3
Residue:
460
Sequence:
MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS
  
Inhibitor
Name:
BDBM50239489
Synonyms:
CHEMBL4100091 | US10329302, Example 121 | US10793579, Example 122 | US11702424, Example 121
Type:
Small organic molecule
Emp. Form.:
C16H17N3O4
Mol. Mass.:
315.3239
SMILES:
COc1cc2c(OC[C@@H]3CCC(=O)N3)nccc2cc1C(N)=O |r|
Structure:
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