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Target
Heat shock factor protein 1
Ligand
BDBM610128
Substrate
n/a
Meas. Tech.
Cell-Based ELISA (Cellisa) Assay
IC50
11.0±n/a nM
Citation
 Jones, K; Rye, C; Chessum, N; Cheeseman, M; Pasqua, AE; Pike, KG; Faulder, PF Fused 1,4-dihydrodioxin derivatives as inhibitors of heat shock transcription factor 1 US Patent  US9701664 Publication Date 7/11/2017 
Target
Name:
Heat shock factor protein 1
Synonyms:
HSF1 | HSF1_HUMAN | HSTF1
Type:
PROTEIN
Mol. Mass.:
57244.20
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1512556
Residue:
529
Sequence:
MDLPVGPGAAGPSNVPAFLTKLWTLVSDPDTDALICWSPSGNSFHVFDQGQFAKEVLPKYFKHNNMASFVRQLNMYGFRKVVHIEQGGLVKPERDDTEFQHPCFLRGQEQLLENIKRKVTSVSTLKSEDIKIRQDSVTKLLTDVQLMKGKQECMDSKLLAMKHENEALWREVASLRQKHAQQQKVVNKLIQFLISLVQSNRILGVKRKIPLMLNDSGSAHSMPKYSRQFSLEHVHGSGPYSAPSPAYSSSSLYAPDAVASSGPIISDITELAPASPMASPGGSIDERPLSSSPLVRVKEEPPSPPQSPRVEEASPGRPSSVDTLLSPTALIDSILRESEPAPASVTALTDARGHTDTEGRPPSPPPTSTPEKCLSVACLDKNELSDHLDAMDSNLDNLQTMLSSHGFSVDTSALLDLFSPSVTVPDMSLPDLDSSLASIQELLSPQEPPRPPEAENSSPDSGKQLVHYTAQPLFLLDPGSVDTGSNDLPVLFELGEGSYFSEGDGFAEDPTISLLTGSEPPKAKDPTVS
  
Inhibitor
Name:
BDBM610128
Synonyms:
N-(5-(2,3-dihydrobenzo[b][1,4]dioxine-6-carboxamido)-2-methylphenyl)-1,7-naphthyridine-3-carboxamide | US9701664, Example 44
Type:
Small organic molecule
Emp. Form.:
C25H20N4O4
Mol. Mass.:
440.4507
SMILES:
Cc1ccc(NC(=O)c2ccc3OCCOc3c2)cc1NC(=O)c1cnc2cnccc2c1
Structure:
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