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Target
Heat shock factor protein 1
Ligand
BDBM610355
Substrate
n/a
Meas. Tech.
Cell-Based ELISA (Cellisa) Assay
IC50
5.00±n/a nM
Citation
 Jones, K; Rye, C; Chessum, N; Cheeseman, M; Pasqua, AE; Pike, KG; Faulder, PF Fused 1,4-dihydrodioxin derivatives as inhibitors of heat shock transcription factor 1 US Patent  US9701664 Publication Date 7/11/2017 
Target
Name:
Heat shock factor protein 1
Synonyms:
HSF1 | HSF1_HUMAN | HSTF1
Type:
PROTEIN
Mol. Mass.:
57244.20
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1512556
Residue:
529
Sequence:
MDLPVGPGAAGPSNVPAFLTKLWTLVSDPDTDALICWSPSGNSFHVFDQGQFAKEVLPKYFKHNNMASFVRQLNMYGFRKVVHIEQGGLVKPERDDTEFQHPCFLRGQEQLLENIKRKVTSVSTLKSEDIKIRQDSVTKLLTDVQLMKGKQECMDSKLLAMKHENEALWREVASLRQKHAQQQKVVNKLIQFLISLVQSNRILGVKRKIPLMLNDSGSAHSMPKYSRQFSLEHVHGSGPYSAPSPAYSSSSLYAPDAVASSGPIISDITELAPASPMASPGGSIDERPLSSSPLVRVKEEPPSPPQSPRVEEASPGRPSSVDTLLSPTALIDSILRESEPAPASVTALTDARGHTDTEGRPPSPPPTSTPEKCLSVACLDKNELSDHLDAMDSNLDNLQTMLSSHGFSVDTSALLDLFSPSVTVPDMSLPDLDSSLASIQELLSPQEPPRPPEAENSSPDSGKQLVHYTAQPLFLLDPGSVDTGSNDLPVLFELGEGSYFSEGDGFAEDPTISLLTGSEPPKAKDPTVS
  
Inhibitor
Name:
BDBM610355
Synonyms:
N-(5-amino-2-((dimethylamino)methyl)phenyl)-2-methylquinoline-6-carboxamide | US9701664, Example 165
Type:
Small organic molecule
Emp. Form.:
C20H22N4O
Mol. Mass.:
334.4149
SMILES:
CN(C)Cc1ccc(N)cc1NC(=O)c1ccc2nc(C)ccc2c1
Structure:
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