Reaction Details Report a problem with these data
Target
Isocitrate dehydrogenase [NADP], mitochondrial
Ligand
BDBM310927
Substrate
n/a
Meas. Tech.
IDH2 Inhibitory Activity
IC50
14.2±n/a nM
Citation
 Wang, S; Zhao, N; Liu, X; Hu, Y; Zhang, H; Luo, H; Peng, Y; Xiao, D; Han, Y; Zhang, X; Tian, X Antitumor compound targeting IDH2 mutation and method of use thereof US Patent  US10155722 Publication Date 12/18/2018 
Target
Name:
Isocitrate dehydrogenase [NADP], mitochondrial
Synonyms:
IDH2 | IDH2 (R172K, 40-end) | IDHP_HUMAN | Isocitrate dehydrogenase 2 (IDH2)
Type:
Protein
Mol. Mass.:
50923.31
Organism:
Homo sapiens (Human)
Description:
Full-length wild-type
Residue:
452
Sequence:
MAGYLRVVRSLCRASGSRPAWAPAALTAPTSQEQPRRHYADKRIKVAKPVVEMDGDEMTRIIWQFIKEKLILPHVDIQLKYFDLGLPNRDQTDDQVTIDSALATQKYSVAVKCATITPDEARVEEFKLKKMWKSPNGTIRNILGGTVFREPIICKNIPRLVPGWTKPITIGRHAHGDQYKATDFVADRAGTFKMVFTPKDGSGVKEWEVYNFPAGGVGMGMYNTDESISGFAHSCFQYAIQKKWPLYMSTKNTILKAYDGRFKDIFQEIFDKHYKTDFDKNKIWYEHRLIDDMVAQVLKSSGGFVWACKNYDGDVQSDILAQGFGSLGLMTSVLVCPDGKTIEAEAAHGTVTRHYREHQKGRPTSTNPIASIFAWTRGLEHRGKLDGNQDLIRFAQMLEKVCVETVESGAMTKDLAGCIHGLSNVKLNEHFLNTTDFLDTIKSNLDRALGRQ
  
Inhibitor
Name:
BDBM310927
Synonyms:
N-cyclopropyl-2,2-difluoro-2-(4-(thiophen-3-yl)-3-(3-(3-(trifluoromethyl)phenyl) ureido)phenyl)acetamide | US10155722, Example 1
Type:
Small organic molecule
Emp. Form.:
C23H18F5N3O2S
Mol. Mass.:
495.465
SMILES:
FC(F)(F)c1cccc(NC(=O)Nc2cc(ccc2-c2ccsc2)C(F)(F)C(=O)NC2CC2)c1
Structure:
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