Reaction Details Report a problem with these data
Target
Epoxide hydrolase 1
Ligand
BDBM409018
Substrate
n/a
Meas. Tech.
Inhibitors of Soluble Epoxide Hydrolase (sEH)
Ki
1.95±0.30 nM
Citation
 Chiamvimonvat, N; Hammock, BD; Sirish, P Methods of improving cell-based therapy US Patent  US11723929 Publication Date 8/15/2023 
Target
Name:
Epoxide hydrolase 1
Synonyms:
EPHX | EPHX1 | EPOX | Epoxide hydrolase (EH) | Epoxide hydrolase (HsEH) | Epoxide hydrolase 1 | HYEP_HUMAN | Microsomal epoxide hydrolase
Type:
Protein
Mol. Mass.:
52954.28
Organism:
Homo sapiens (Human)
Description:
P07099
Residue:
455
Sequence:
MWLEILLTSVLGFAIYWFISRDKEETLPLEDGWWGPGTRSAAREDDSIRPFKVETSDEEIHDLHQRIDKFRFTPPLEDSCFHYGFNSNYLKKVISYWRNEFDWKKQVEILNRYPHFKTKIEGLDIHFIHVKPPQLPAGHTPKPLLMVHGWPGSFYEFYKIIPLLTDPKNHGLSDEHVFEVICPSIPGYGFSEASSKKGFNSVATARIFYKLMLRLGFQEFYIQGGDWGSLICTNMAQLVPSHVKGLHLNMALVLSNFSTLTLLLGQRFGRFLGLTERDVELLYPVKEKVFYSLMRESGYMHIQCTKPDTVGSALNDSPVGLAAYILEKFSTWTNTEFRYLEDGGLERKFSLDDLLTNVMLYWTTGTIISSQRFYKENLGQGWMTQKHERMKVYVPTGFSAFPFELLHTPEKWVRFKYPKLISYSYMVRGGHFAAFEEPELLAQDIRKFLSVLERQ
  
Inhibitor
Name:
BDBM409018
Synonyms:
US10377744, Compound No. 38 | US11123311, Compound 38 | US11723929, Compound 38
Type:
Small organic molecule
Emp. Form.:
C15H8F8N2O3
Mol. Mass.:
416.2228
SMILES:
Fc1cc(NC(=O)Nc2ccc(OC(F)(F)F)c(F)c2)ccc1OC(F)(F)F
Structure:
Search PDB for entries with ligand similarity: