Reaction Details Report a problem with these data
Target
Epoxide hydrolase 1
Ligand
BDBM409022
Substrate
n/a
Meas. Tech.
Inhibitors of Soluble Epoxide Hydrolase (sEH)
Ki
45.0±2.3 nM
Citation
 Chiamvimonvat, N; Hammock, BD; Sirish, P Methods of improving cell-based therapy US Patent  US11723929 Publication Date 8/15/2023 
Target
Name:
Epoxide hydrolase 1
Synonyms:
EPHX | EPHX1 | EPOX | Epoxide hydrolase (EH) | Epoxide hydrolase (HsEH) | Epoxide hydrolase 1 | HYEP_HUMAN | Microsomal epoxide hydrolase
Type:
Protein
Mol. Mass.:
52954.28
Organism:
Homo sapiens (Human)
Description:
P07099
Residue:
455
Sequence:
MWLEILLTSVLGFAIYWFISRDKEETLPLEDGWWGPGTRSAAREDDSIRPFKVETSDEEIHDLHQRIDKFRFTPPLEDSCFHYGFNSNYLKKVISYWRNEFDWKKQVEILNRYPHFKTKIEGLDIHFIHVKPPQLPAGHTPKPLLMVHGWPGSFYEFYKIIPLLTDPKNHGLSDEHVFEVICPSIPGYGFSEASSKKGFNSVATARIFYKLMLRLGFQEFYIQGGDWGSLICTNMAQLVPSHVKGLHLNMALVLSNFSTLTLLLGQRFGRFLGLTERDVELLYPVKEKVFYSLMRESGYMHIQCTKPDTVGSALNDSPVGLAAYILEKFSTWTNTEFRYLEDGGLERKFSLDDLLTNVMLYWTTGTIISSQRFYKENLGQGWMTQKHERMKVYVPTGFSAFPFELLHTPEKWVRFKYPKLISYSYMVRGGHFAAFEEPELLAQDIRKFLSVLERQ
  
Inhibitor
Name:
BDBM409022
Synonyms:
US10377744, Compound No. 42 | US11123311, Compound 42 | US11723929, Compound 42
Type:
Small organic molecule
Emp. Form.:
C17H23F3N4O2
Mol. Mass.:
372.3853
SMILES:
CC[C@H](C)C(=O)N1CCC(CC1)NC(=O)Nc1ccc(nc1)C(F)(F)F |r|
Structure:
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